Comparative analysis of bioactive constituents and pharmacological activities from different parts of Nauclea officinalis

Abstract

The stems of Nauclea officinalis have been utilized as a crude drug in China, so other parts of the plant are abandoned, resulting in a waste of traditional Chinese medicine resources. To determine the distribution and content of the alkaloids, phenolic acids and iridoid in different organs (stem, branch, leaf and bark) of this plant, a reliable method has been established using LC-MS/MS. Nine constituents, namely strictosamide, vincosamide, chlorogenic acid, sweroside, naucleamide B, protocatechuic acid, pumiloside, vanillic acid and cryptochlorogenic acid, were simultaneously determined in 6 min. Meanwhile, the antipyretic, anti-inflammatory and analgesic activities were evaluated for comparative analysis of the pharmacological activity of different parts of N. officinalis. The results showed that the content of active components in other organs of N. officinalis was higher than that in stems, and the pharmacological effects of branches and leaves were also better. The established approach could be helpful for the quality control of N. officinalis, and also provide necessary information for the rational utilization of resources.

Vincosamide Has a Function for Inhibiting Malignant Behaviors of Hepatocellular Carcinoma Cells

“…Monoterpene indolic alkaloid (N-β-glucopyranosyl vincosamide) is the main component of extracts from the leaves of Psychotria leiocarpa, which is found in tropical and subtropical regions. Many studies have shown that Vinco has anti-inflammatory activities in vivo and anti-proliferative effects in vitro [1,7,[24][25][26]; and Vinco also has cytotoxic, anthelmintic, analgesic, anti-bactericidal activities [2,[27][28][29] and with potential therapeutic effects on type 2 diabetes [30]. Evidence indicated Vinco as protective agent in cardiac damage and vascular dysfunction [31].…”

Measurement of Pharmacokinetics and Tissue Distribution of Four Compounds from Nauclea officinalis in Rat Plasma and Tissues through HPLC-MS/MS

“…ex Pitard, is one of the most commonly used traditional medicines in China and is mainly distributed in Hainan, Guangxi, Guangdong, and other provinces in the south of China [1]. Modern pharmacological studies reported that Nauclea ofcinalis exhibits various biological properties such as antibacterial, anti-infammatory, and analgesic activity [2][3][4][5][6]. As a traditional Chinese medicine, the stems and twigs of Nauclea ofcinalis are used for the treatment of colds, fever, acute tonsillitis, sore throat, and other diseases [1,7].…”