Comparative Analysis of Bone Mechanical Properties of Adipose-Derived Mesenchymal Stem Cells and Raloxifene in Treatment of Osteoporosis

Abstract

This study aims to compare the bone mechanical properties of adipose-derived mesenchymal stem cells (ADM-SCs) and raloxifene in treating osteoporosis and to provide related biomechanical basis. The serum of animal model of osteoporosis was sampled after ADMSCs or raloxifene intervention and measured BALP, TRACP-5b, MMP-9, and Cath-K the femur was taken for compression test, tibia for shock test, vertebrae for bone mineral densitytest, humerus for histomorphometric index test. In Group AMSCs, BMD and BALP were higher than those in Group MOD, in Group RAL, TRACP-5b, MMP-9 mL-1 and Cath-K were lower than those in Group MOD with significant differences (p < 0.05). In Group AM-SCs, BMD, BALP, and such mechanical performance indexes as maximum compressive load, maximum stress, maximum strain, elastic modulus, shock energy, and shock toughness were significantly larger than Group MOD and Group RAL (p < 0.05). After AMSCs intervention, the bone quality can be improved, and the compression and shock mechanical properties can be restored.