Comparative analysis of C-glycosidic flavonoids from Prosopis spp. and Ceratonia siliqua seed germ flour

Picariello, Gianluca; Sciammaro, Leonardo Pablo; Siano, Francesco; Volpe, Maria Grazia; Puppo, Marı́a Cecilia; Mamone, Gianfranco

doi:10.1016/j.foodres.2017.06.058

Cited by 57 publications

(34 citation statements)

References 46 publications

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“…Flavones: Peaks 5–7 and 9–13 presented all similar UV-spectra (λ max at 324–338 nm) and a fragmentation pattern characteristic of C -hexosyl-flavones, and similar to those observed by Picariello et al., 2017. Peaks 5, 6 and 7 showed a UV-vis spectra with a maximum wavelength of absorption at 324 nm, a precursor ion [M-H] - at m/z 725 and different fragments at m/z 635 and 605, that corresponded to the loss of 90 and 120 mu, which are characteristics of C -hexosyl flavones (Ferreres et al., 2003).…”

Section: Resultssupporting

confidence: 77%

In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)

Rico

Martín-Diana

Martínez‐Villaluenga

et al. 2019

Heliyon

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The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g−1, respectively). Pod mostly contained gallic acid and gallotannins; seed peel and germ's showed as most abundant polyphenols quercetin and apigenin derivatives. Carob pod and seed peel revealed stronger antioxidant capacities compared to germ. The strongest antihypertensive activity was found in seed peel, followed by pod and germ. Anti-inflammatory activity showed inhibition of NO production in LPS-induced macrophages, although only pod was able of reducing pro-inflammatory mediators (TNF-α andPGD2). Finally, fat accumulation on mature adipocytes was reduced by carob seed peel and pod extracts. This work shows the potential use of pod carob by-products as food ingredients with special relevance of carob pod for attenuating metabolic syndrome.

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Section: Resultssupporting

confidence: 77%

In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)

Rico

Martín-Diana

Martínez‐Villaluenga

et al. 2019

Heliyon

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“…1). Similar compounds were previously reported to P. alba cotyledons flour [3, 14], and P. alba mesocarp flour [15, 16]. Isovitexin has been reported as antioxidant and anti-inflammatory [17, 18], properties that may contribute to its protective effects on cardiovascular diseases [19].…”

Section: Resultssupporting

confidence: 78%

Prosopis alba seed flour improves vascular function in a rabbit model of high fat diet-induced metabolic syndrome

Cattaneo

Roco

Alarcón

et al. 2019

Heliyon

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Aims Prosopis alba flour is a natural source of nutrient and phytochemicals with potential effects on cardiovascular risk factors. The aim of this work was to examine the effects of dietary supplementation with Prosopis alba seed flour (Pr-Feed) on a high fat diet (FD)-induced rabbit model of metabolic syndrome. Main methods Rabbits were separated in four groups: fed regular diet (CD); CD supplemented with Pr-Feed; fed on 18 % FD; FD supplemented with Pr-Feed. All diets were administrated for 6 weeks. After the feeding period body weights, mean blood pressure, heart rate and visceral abdominal fat (VAF) were determined; glucose tolerance test (GTT) was performed; total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides (TG), fasting glucose (FG), aspartate amino transferase, alanine amino transferase, bilirubin and creatinine were measured in serum. Abdominal aorta was excised and vascular function was assessed by acetylcholine relaxation and contractile response to KCl, norepinephrine and angiotensin II. Key findings Phytochemical analyses showed that the main compounds of Pr-Feed were apigenin C-glycosides. FD increased VAF, FG, TG, reduced HDL-cholesterol and induced abnormal GTT. Pr-Feed addition to FD did not modify these alterations. Aortic rings from rabbits fed on FD exhibited an impaired relaxation-response to acetylcholine and increased agonist vasoconstrictor responses. Pr Feed-supplemented FD improved the response to acetylcholine, and prevented the increase of the contractile response to KCl, norepinephrine and angiotensin II. Significance Results suggest that dietary supplementation with Pr-Feed, rich in apigenin C-glycosides, has vascular protector properties and could be used to prevent vascular alterations characterizing the metabolic syndrome.

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“…In addition, apigenin 6,8-C-di-glycosides were found as potent α-glucosidase inhibitors, suggesting that food preparations obtained from Prosopis spp. and seed germ flour might contribute to carbohydrates digestion modulation in humans [139]. Another study performed in Mexico [6], showed that pollen of P. juliflora is an important source of flavonoids, that can be considered as a natural source of antioxidant compounds, and that the effect is related to the flavonol concentration, although when a high amount of flavonols is used, the extract of mesquite pollen can have pro-oxidant effects [6].…”

Section: Nutritional Attributes Beyond Health Promotionmentioning

confidence: 99%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

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Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

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Comparative analysis of C-glycosidic flavonoids from Prosopis spp. and Ceratonia siliqua seed germ flour

Cited by 57 publications

References 46 publications

In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)

In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)

Prosopis alba seed flour improves vascular function in a rabbit model of high fat diet-induced metabolic syndrome

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

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