Twenty years ago, the field of Robotics was defined and galvanized by the creation of an IEEE Journal devoted to the topic. We now have the opportunity to do the same for the field of Automation. The IEEE voted in February 2003 to bifurcate the IEEE Transactions on Robotics and Automation, the top-cited archival publication on robotics. The renamed Transactions on Robotics will gain a sibling: the Transactions on Automation Science and Engineering. T-ASE will publish foundational research on Automation: scientific methods and technologies that improve efficiency, productivity, quality, and reliability, specifically for methods, machines, and systems operating in structured environments over long periods, and the explicit structuring of environments. Its coverage will go beyond Automation's roots in mass production and include many new applications areas, such as Biotechnology, pharmaceutical, and health care; Home, service, and retail; Construction, transportation, and security; Manufacturing, maintenance, and supply chains; and Food handling and processing. Research includes topics related to robots and intelligent machines/systems in structured environments and the explicit structuring of environments, and topics at the Operational/Enterprise levels such as System Modeling,