Comparative Analysis of Clinicopathologic Features of, Treatment in, and Survival of Americans with Lung or Bronchial Cancer

Abstract

Ethnic disparities in lung and bronchial cancer diagnoses and disease-specific survival (DSS) rates in the United States are well known. However, few studies have specifically assessed these differences in Asian subgroups. The primary objectives of the retrospective analysis described herein were to identify any significant differences in clinicopathologic features, treatment, and survival rate between Asian lung cancer patients and lung cancer patients in other broad ethnic groups in the United States and to determine the reasons for these differences among subgroups of Asian patients with lung or bronchial cancer. We searched the Surveillance, Epidemiology, and End Results Program database to identify patients diagnosed with lung or bronchial cancer from 1990 to 2012. Differences in clinicopathologic features, treatment, and DSS rate in four broad ethnic groups and eight Asian subgroups were compared. The study population consisted of 849,088 patients, 5.2% of whom were of Asian descent. Female Asian patients had the lowest lung and bronchial cancer incidence rates, whereas male black patients had the highest rates. Asian patients had the best 5-year DSS rate. In our Asian subgroup analysis, Indian/Pakistani patients had the best 5-year DSS rate, whereas Hawaiian/Pacific Islander patients had the worst 5-year DSS rates. We found the differences in DSS rate among the four broad ethnic groups and eight Asian subgroups when we grouped patients by age and disease stage, as well. Asian patients had better DSS rates than those in the other three broad ethnic groups in almost every age and disease-stage group, especially in older patients and those with advanced-stage disease. In conclusion, we found that clinicopathologic features and treatment of lung and bronchial cancer differ by ethnicity in the United States, and the differences impact survival in each ethnic group.

Prognostic Significance of Stromal Periostin Expression in Non-Small Cell Lung Cancer

“…Lung cancer remains the leading cancer worldwide with regard to incidence and mortality rates [ 1 , 2 ]. Most lung cancers are classified as non-small-cell lung cancers (NSCLCs—85%) or small-cell lung cancers (SCLC—15%) [ 1 , 2 , 3 ].…”

“…Lung cancer remains the leading cancer worldwide with regard to incidence and mortality rates [ 1 , 2 ]. Most lung cancers are classified as non-small-cell lung cancers (NSCLCs—85%) or small-cell lung cancers (SCLC—15%) [ 1 , 2 , 3 ]. While there are rare types of NSCLCs, the three most prevalent histological types include adenocarcinomas (ACs), squamous cell carcinomas (SCCs), and large-cell carcinomas (LCCs) [ 3 , 4 ].…”

Advancing Aptamers as Molecular Probes for Cancer Theranostic Applications—The Role of Molecular Dynamics Simulation

“…Skin, pancreatic, ovarian, and cervical cancers are the types that usually specific to gender or geography. Further, bladder, bronchial, stomach/intestinal, and bile duct cancer types are considered as rare. Epidermal growth factor receptor is the most common biomarker used to diagnose these rare cancers .…”

Gene polymorphism of DNA repair gene X‐ray repair cross complementing group 1 and xeroderma pigmentosum group D and environment interaction in non‐small‐cell lung cancer for Chinese nonsmoking female patients

“…Lung cancer is one of lethal cancers in the world, and the five‐year survival rate is around 6%‐16% . The two main types of lung cancer are small cell lung cancer (SCLC) and non‐small‐cell lung cancer (NSCLC), of which, NSCLC accounts for 85%‐90% of lung cancers, while SCLC has been decreasing in frequency in many countries over the last two decades .…”

“…Lung cancer is one of lethal cancers in the world, and the five-year survival rate is around 6%-16%. 1 The two main types of lung cancer are small cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC), of which, NSCLC accounts for 85%-90% of lung cancers, while SCLC has been decreasing in frequency in many countries over the last two decades. 2,3 There are several known risk factors including cigarette smoking, second-hand tobacco smoking, diet and food supplements, alcohol, few exercise and physical activity, air pollution and occupational exposure.…”