Comparative Analysis of Complex Programs of Renewal Treatment of Patients with Chronic Pancreatitis

Abstract

Aim: To conduct a comparative analysis of the dynamics of heart rate variability parameters in CP patients with autonomic dysfunction under the influence of the proposed complex treatment programs with the additional inclusion of the vegetative stabilizing agent memoplant and a combination of complex bioregulatory drugs. Materials and Methods: Statistical and spectral parameters of heart rate variability were analyzed in 69 patients with CP before and after outpatient treatment. Patients were divided into 3 groups of 23 patients with CP: group 1 – received conventional treatment (CT) according to the clinical diagnosis and the protocol proposed by the Ministry of Health of Ukraine (Order No. 638 of 10.09.2014); group 2 – CT enhanced with a course of the vegetative-stabilizing drug ginkgo biloba (memoplant); 3 group – CT with a course of memoplant and complex bioregulatory therapy (BRT): momordica compositum, traumeel S and neurexan according to the proposed scheme. Results: In group 1, the stress index (SI) decreased by 18.49%, p<0.05, vegetative reactivity (VR) increased by 21.31%, p<0.05, IARS decreased by 25.79%, p<0.01. In group 2, a more significant decrease in sympathicotonia was observed: SI decreased by 38.17% (p<0.01), mode amplitude (АМо) by 14.57% (p<0.05), the range of variation (X) increased by 12.78% (p<0.05); IARS decreased by 44.55 % (p<0.01) to moderate tension. There was an increase in the total spectrum power (TP) (by 29.21%, p<0.01) and components: LF increased by 37.03% (p<0.01) relative to the initial level, HF by 64.01% (p<0.01), VLF by 8.75% (p<0.05). In patients of group 3, normalization of SI and АМо was observed (indicators decreased by 48.42% and 19.98%, p<0.01), X increased by 17.35%, p<0.01; The VR level did not differ significantly from the control (1.16±0.06 and 1.25±0.10, respectively). IARS decreased by 56.18% (p<0.01); TP increased by 49.61% (p<0.01), LF by 76.78% (p<0.01), HF by 117.67% (p<0.01), VLF by 8.41% (p<0.05). Conclusions: In patients with CP, a higher efficiency of treatment programs with the inclusion of ginkgo biloba and complex bioregulatory therapy on the state of autonomic regulation was established compared to the generally accepted program in terms of spectral and statistical parameters of heart rate variability.