Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma

Evangelista, Mara Therese P.; North, Jeffrey P.

doi:10.1111/cup.12546

Cited by 37 publications

(46 citation statements)

References 26 publications

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“…CK20 can be used in combination with androgen receptor (AR), with positive tumor AR staining and absent CK20 staining supporting BCC, whereas CK20 þ colonizing Merkel cells and lack of AR support a benign diagnosis. [54][55][56] Several limitations of the AR/CK20 panel should be kept in mind. The AR expression is often focal and sometimes completely absent in BCC.…”

Section: Benign Hair-germ Tumors (Trichoepithelioma Andmentioning

confidence: 99%

“…61,64,68,69 Although p75NTR is more likely to show diffuse expression in DTE than in mBCC, 70 a later study 71 demonstrated limited specificity, with diffuse expression in 36% of mBCC and 44% of microcystic adnexal carcinomas. In recent studies, strong and diffuse expression of PHLDA1 (TDAG51), a follicular stem-cell marker, has been shown to be highly specific for TE/TB, 53,55,72 although expression in micronodular BCC has been reported. 72 In summary, although markers, including AR, CK20, and PHLDA1, may be useful in distinguishing BCC from benign, hair-germ tumors, no single marker appears completely sensitive or specific for this distinction.…”

Section: Benign Hair-germ Tumors (Trichoepithelioma Andmentioning

confidence: 99%

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Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Benign Hair-germ Tumors (Trichoepithelioma Andmentioning

confidence: 99%

Section: Benign Hair-germ Tumors (Trichoepithelioma Andmentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…21 Even cases of infundibulocystic BCC show the same pattern of focal staining for ARs. 21 This is in contrast to the expression of ARs by sebaceous tumors, which is usually seen in >25% of the tumoral cells.…”

Section: Discussionmentioning

confidence: 97%

“…18 Interestingly, most of the structures of the normal follicle are AR negative, and this is also probably why most adnexal tumors showing follicular differentiation are also AR negative, such as pilomatrixomas, 19 trichoadenomas, 20 or desmoplastic trichoepitheliomas. 20,21 Focal immunoexpression of AR has been described in BCC, 2 usually limited to <25% of the cells in most of the cases tested. 21 Even cases of infundibulocystic BCC show the same pattern of focal staining for ARs.…”

Section: Discussionmentioning

confidence: 99%

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Immunoexpression of Androgen Receptors in Poroid Neoplasms

Fernández-Flores

Cassarino²

2017

Applied Immunohistochemistry &Amp; Molecular Morphology

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Some poroid neoplasias are known to show apocrine differentiation (ie, differentiation toward the folliculosebaceous and the apocrine units). In this sense, it is somewhat surprising that the immunoexpression of androgen receptors (ARs) has not been investigated yet in poroid neoplasias. In this study, we examined the immunoexpression of ARs in 40 poroid neoplasms (8 porocarcinomas and 32 poromas). We found intense and diffuse immunoexpression of ARs in 1 porocarcinoma. In addition, 7 poromas and 2 porocarcinomas showed focal immunoexpression of ARs. Nine of these 10 positive cases were found in men. We conclude that poroid neoplasias express ARs in about 25% of the cases, but the expression is usually focal/weak. However, the expression of this marker is not incompatible with a diagnosis of poroid neoplasia.

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Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

Worley

Owen²,

Barker

et al. 2019

JAMA Dermatol

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IMPORTANCE Microcystic adnexal carcinoma (MAC) occurs primarily in older adults of white race/ethnicity on sun-exposed skin of the head and neck. There are no formal guiding principles based on expert review of the evidence to assist clinicians in providing the highest-quality care for patients. OBJECTIVE To develop recommendations for the care of adults with MAC.EVIDENCE REVIEW A systematic review of the literature (1990 to June 2018) was performed using MEDLINE, Embase, Web of Science, and the Cochrane Library. The keywords searched were microcystic adnexal carcinoma, sclerosing sweat gland carcinoma, sclerosing sweat duct carcinoma, syringomatous carcinoma, malignant syringoma, sweat gland carcinoma with syringomatous features, locally aggressive adnexal carcinoma, and combined adnexal tumor. A multidisciplinary expert committee critically evaluated the literature to create recommendations for clinical practice. Statistical analysis was used to estimate optimal surgical margins.

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Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma

Cited by 37 publications

References 26 publications

Histologic Mimics of Basal Cell Carcinoma

Histologic Mimics of Basal Cell Carcinoma

Immunoexpression of Androgen Receptors in Poroid Neoplasms

Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma

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