Comparative analysis of cytotoxic and antioxidant potential of edible Cinnamomum verum (bark) and Cinnamomum tamala (Indian bay leaf)

Abstract

a b s t r a c tBackground: Cinnamomum verum bark (Cinnamon or dalchini in Hindi) and Cinnamomum tamala leaf (Indian bay leaf or tejpatta in Hindi) are commonly used spices in the Asian subcontinent. In the present study, we compared the bioactive potential of these spices. Method: The plants were collected and extracted with different solvents. The extracts were analysed for in vitro cytotoxicity against human cancer cell lines by SRB assay. Antioxidant activity was measured in terms of DPPH radical scavenging and chelation power on ferrous ions. Relative phenolic content of extracts was also measured. Results: Comparative analysis demonstrated that C. verum (bark) has much greater cytotoxic as well as antioxidant potential than C. tamala (leaves). The bark methanol extract showed potential activity against prostrate (PC-3) and glioblastoma (T98G) cancer cell lines with 90% and 78% growth inhibition at 100 mg/ ml concentration respectively. The bark methanol extract also showed good DPPH free radical scavenging activity with IC 50 111.5 AE 0.62 mg/ml and moderate chelating power on ferrous ions IC 50 108.7 AE 0.53 mg/ ml. The total phenolic content of bark methanol extract was highest with 210 AE 0.81 mg/g GAE. Conclusion: This study highlights the relative greater bioactive potential of C. verum (bark) and it can be deduced that it is a highly effective cytotoxic, antioxidant spice than Indian bay leaf.

Assessment of changes in biophysical parameters by dermocosmetic emulgel loaded with Cinnamomum tamala extract: A split‐faced and placebo‐controlled study

“…Any material that causes the inhibition of 5‐α‐reductase has the ability to inhibit the synthesis of active metabolite dihydrotestosterone and sebum secretion . Phenolic compounds in C tamala leaf include kaempferol, quercetin, and quercetin which are found to be responsible for the inhibition of 5‐α‐reductase, thus eventually decrease the sebum secretion as stated in the literature . Subsequently, CT emulgel application leads to the gradual reduction in sebum secretion throughout the study period.…”

“…Being rich in flavonoids and phenolic compounds, CT extract ascertains the beneficial antioxidant effects because a significant correlation has previously been indicated between the phenolic content and antioxidant activity. 17 A study has reported that antioxidants found in botanical extracts may cause a reduction in skin melanin content. 18 Moreover, flavonoids also possess the aptitude to reduce melanin production by showing inhibitory action for tyrosinase enzyme, which plays a vital role in melanin biosynthesis.…”

“…Current study showed the continuous and significant decline in skin melanin content with use of CT emulgel that can be accredited to the presence of phenolic and flavonoid compounds in CT extract. Being rich in flavonoids and phenolic compounds, CT extract ascertains the beneficial antioxidant effects because a significant correlation has previously been indicated between the phenolic content and antioxidant activity . A study has reported that antioxidants found in botanical extracts may cause a reduction in skin melanin content .…”

Comparative Analysis of In vitro Antimicrobial and Antioxidant Potential of Cinnamomum tamala Extract and their Essential Oils of Two Different Chemotypes

“…Antioxidant activity of Cinnamon leaf oils was reported by Padalia (2015) and Kapoor (2009). Similarly Sudan et al, (2013), reported that methanolic extract has shown higher activity than the aqueous extract of Cinnamomum cassia and Cinnamomum tamala leaf, Pandey et al, (2012), also showed that the aquous extract of C. tamalahad less activity as compared to alcoholic extract.…”

Phenolic compounds from kenaf (Hibiscus cannabinus L.) seeds by ultrasound-assisted extraction

“…4 The addition of plant antioxidants to processed foods is becoming increasingly important in the food industry as an alternative to synthetic antioxidants. 5 Ultrasonic-assisted extraction was used to extract the kenaf seed because it is offering advantages such as improved efficiency, reduced extraction time, low solvent consumption, and a high level of automation relative to conventional extraction techniques. 6 To the best of our knowledge, very little information has been reported on the purification of phenolic compounds in kenaf seeds.…”