Generative Adversarial Networks (GANs) have surfaced as a transformative approach in the domain of cryptography, introducing a novel paradigm where two neural networks, the generator (akin to Alice) and the discriminator (akin to Bob), are pitted against each other in a cryptographic setting. A third network, representing Eve, attempts to decipher the encrypted information. The efficacy of this encryption–decryption process is deeply intertwined with the choice of activation functions employed within these networks. This study conducted a comparative analysis of four widely used activation functions within a standardized GAN framework. Our recent explorations underscore the superior performance achieved when utilizing the Rectified Linear Unit (ReLU) in the hidden layers combined with the Sigmoid activation function in the output layer. The non-linear nature introduced by the ReLU provides a sophisticated encryption pattern, rendering the deciphering process for Eve intricate. Simultaneously, the Sigmoid function in the output layer guarantees that the encrypted and decrypted messages are confined within a consistent range, facilitating a straightforward comparison with original messages. The amalgamation of these activation functions not only bolsters the encryption strength but also ensures the fidelity of the decrypted messages. These findings not only shed light on the optimal design considerations for GAN-based cryptographic systems but also underscore the potential of investigating hybrid activation functions for enhanced system optimization. In our exploration of cryptographic strength and training efficiency using various activation functions, we discovered that the “ReLU and Sigmoid” combination significantly outperforms the others, demonstrating superior security and a markedly efficient mean training time of 16.51 s per 2000 steps. This highlights the enduring effectiveness of established methodologies in cryptographic applications. This paper elucidates the implications of these choices, advocating for their adoption in GAN-based cryptographic models, given the superior results they yield in ensuring security and accuracy.