Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation

Abstract

Context:Laryngoscopy and intubation cause an intense reflex increase in heart rate, blood pressure, due to an increased sympathoadrenal pressor response. Lignoocaine has shown blunting of pressor response to intubation. Dexmedetomidine has sympatholytic effects.Aims:To the best of our knowledge there is no study comparing the efficacy of lignocaine with two different doses of dexmedetomidine for attenuating the pressor response. With this idea, we planned to conduct the present study.Materials and Methods:After approval by the Hospital Ethics committee, 90 consenting adults aged 18-65 years of age of either sex of non-hypertensive ASA Grade I or II were randomly allocated into three groups. Group D1- IV Dexmedetomidine 0.5μg/kg over 10 minutes Group D2- IV Dexmedetomidine 1μg/kg over 10 minutes Group X- IV Lignocaine 1.5mg/kg in 10 ml normal salineStatistical Analysis Used:ANOVA and Student's t test used for analysis.Results:Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.Conclusions:We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

“…It is found that intravenous dexmedetomidine is more effective in attenuating the hemodynamic response to laryngoscopy and intubation than other agents [3,[20][21][22].…”

Effects of Preanesthetic Single Dose Intravenous Dexmedetomidine Versus Fentanyl on Hemodynamic Response to Endotracheal Intubation - A Clinical Comparative Study

“…1 Both fentanyl and dexmedetomidine is known to decrease the manifestation of sympathetic nervous system activation. 1,[4][5][6][7][8][9][10][11][12][13] In the present study, heart rate significantly decreased in the dexmedetomidine group when compared to fentanyl group immediately after study drug infusion and there was statistically significant reduction in heart rate for up to 5 min after intubation in both the groups. Although heart rate increased after intubation in both the groups, the magnitude was lower in the Dexmedetomidine group.…”

“…3 Its usefulness in prevention of haemodynamic response to laryngoscopy and intubation has been the interest of present research. [4][5][6][7][8][9][10][11][12][13] Propofol is the most commonly used J Evid Based Med Healthc, pISSN-2349-2562, eISSN-2349-2570/ Vol. 2/Issue 59/Dec.…”

Intravenous dexmedetomidine 1µg/kg as premedication to attenuate hemodynamic response to laryngoscopy and endotracheal intubation in surgeries under general anesthesia

“…Various authors had also considered injection Dexmedetomedine for attenuation and hemodynamic stability. 8,[13][14][15]21 Sujit sulaiman et al, Menda F et al had studied and demonstrated that α2 adrenoreceptor agonists can beneficially modulate coronary blood flow by preventing transmural redistribution of blood flow by specific epicardially vasoconstriction effects leading to improvement in endocardial perfusion and lower heart rate. 20,21 So role of Dexmedetomidine was not limited for attenuation of pressure response in healthy patients but also in cardiac patients where it plays cardioprotective role.…”

“…8,[13][14][15] They compared different doses of inj. Dexmedetomidine to study dose dependent efficacy.…”