Knowledge about financial performance is considered very important for companies and investors. This research aims to compare the financial performance of two of Indonesia's top five pharmaceutical companies. This research uses financial ratio analysis, namely liquidity ratios, solvency ratios, activity ratios, profitability ratios, and market ratios. The method used in this research is comparative research using statistical analysis. The results of this research show that the first company has a higher liquidity and profitability ratio. In contrast, the second company has a better capacity to meet its interest obligations, even though its financial performance is more volatile. There were significant differences in twelve ratios between the two companies, and no significant differences were found in the other six ratios. Research findings can be a basis for the market to view that the first company has more potential to grow in the future and support the decision-making process for stakeholders.