Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks

Pukhovskaya, N. M.; Морозова, О. В.; Belozerova, Nadejda B.; Bakhmetyeva, Svetlana V.; Высочина, Н. П.; Zdanovskaya, Nina I.; Иванов, Л. И.

doi:10.18821/0507-4088-2017-62-1-30-35

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The European subtype has been found in the territory of South Korea [8], Altai, and Irkutsk Region. The Siberian variant circulates in Scandinavia [9], the Baltic [10], Sakhalin [11], Bosnia [12], and Central Asia [13,14]. The Far-Eastern subtype has been detected in Southern Siberia, in the Urals, in the Baltic [10], and in Moldova [15].…”

Section: Introductionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus: An Emerging Ancient Zoonosis?

Deviatkin

Kholodilov

Vakulenko

et al. 2020

Viruses

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Tick-borne encephalitis (TBE) is one of the most important viral zoonosis transmitted by the bite of infected ticks. In this study, all tick-borne encephalitis virus (TBEV) E gene sequences available in GenBank as of June 2019 with known date of isolation (n = 551) were analyzed. Simulation studies showed that a sample bias could significantly affect earlier studies, because small TBEV datasets (n = 50) produced non-overlapping intervals for evolutionary rate estimates. An apparent lack of a temporal signal in TBEV, in general, was found, precluding molecular clock analysis of all TBEV subtypes in one dataset. Within all subtypes and most of the smaller groups in these subtypes, there was evidence of many medium- and long-distance virus transfers. These multiple random events may play a key role in the virus spreading. For some groups, virus diversity within one territory was similar to diversity over the whole geographic range. This is best exemplified by the virus diversity observed in Switzerland or Czech Republic. These two countries yielded most of the known European subtype Eu3 subgroup sequences, and the diversity of viruses found within each of these small countries is comparable to that of the whole Eu3 subgroup, which is prevalent all over Central and Eastern Europe. Most of the deep tree nodes within all three established TBEV subtypes dated less than 300 years back. This could be explained by the recent emergence of most of the known TBEV diversity. Results of bioinformatics analysis presented here, together with multiple field findings, suggest that TBEV may be regarded as an emerging disease.

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Section: Introductionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus: An Emerging Ancient Zoonosis?

Deviatkin

Kholodilov

Vakulenko

et al. 2020

Viruses

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“…Hereinafter, we adhere to the traditional term, subtype, to designate the first taxonomic unit below the TBEV species level. In recent decades, there has been a growing body of evidence that subtypes can be isolated far from their nominal geographic region [8][9][10][11][12][13][14][15][16][17]. Subspecies taxonomy of TBEV was further complicated by the discovery of viruses that could not be unambiguously assigned to known subtypes.…”

Section: Introductionmentioning

confidence: 99%

TBEV Subtyping in Terms of Genetic Distance

Deviatkin

Karganova

Vakulenko

2020

Viruses

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Currently, the lowest formal taxon in virus classification is species; however, unofficial lower-level units are commonly used in everyday work. Tick-borne encephalitis virus (TBEV) is a species of mammalian tick-borne flaviviruses that may cause encephalitis. Many known representatives of TBEV are grouped into subtypes, mostly according to their phylogenetic relationship. However, the emergence of novel sequences could dissolve this phylogenetic grouping; in the absence of strict quantitative criterion, it may be hard to define the borders of the first TBEV taxonomic unit below the species level. In this study, the nucleotide/amino-acid space of all known TBEV sequences was analyzed. Amino-acid sequence p-distances could not reliably distinguish TBEV subtypes. Viruses that differed by less than 10% of nucleotides in the polyprotein-coding gene belonged to the same subtype. At the same time, more divergent viruses were representatives of different subtypes. According to this distance criterion, TBEV species may be divided into seven subtypes: TBEV-Eur, TBEV-Sib, TBEV-FE, TBEV-2871 (TBEV-Ob), TBEV-Him, TBEV-178-79 (TBEV-Bkl-1), and TBEV-886-84 (TBEV-Bkl-2).

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Relevance of Parasitological Research in the South of the Russian Far East

Voronova¹,

Табакаева²,

Vainutis³

et al. 2021

PH&LE

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Background: The south of the Russian Far East including the Amur Region, the Jewish Autonomous Region, the Khabarovsk and Primorsky Regions is a unique area in terms of richness of the parasite fauna. Historically, ideal conditions for the existence of various foci of parasitic infections have formed locally. The objective of our study was to provide a brief description of the history of parasitological studies conducted in the south of the Russian Far East since the first half of the 20th century and to demonstrate their relevance. Materials and methods: We analyzed appropriate literary sources found in the Web of Science, PubMed, Scopus, Elsevier, Springer, and Google Scholar databases. Results: We established that the species diversity of trematodes was studied better than that of cestodes, nematodes, higher and lower monogeneans. The accumulated knowledge is fundamental for understanding distribution and pathogenicity of helminths. However, contemporary parasitological research is characterized by a high level of interdisciplinarity and integration. A simple systematization of parasites is no longer enough; it is necessary to characterize molecular mechanisms underlying pathogenesis, antigenic variability, and drug resistance. The article discusses perspectives of future parasitological research of the biology of endo- and ectoparasites, host–parasite interactions and links at different levels of organization: biocenotic, population and organismic, complementing theoretical data on the processes of microevolution and coevolution of the pathogen and the host. Conclusion: Existing problems can be solved using proteomic, genomic, transcriptomic, and bioinformatics approaches that contribute to a better understanding of the biology of objects and are promising for identification of clinically important biological characteristics of parasitic organisms.

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Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks

Cited by 5 publications

References 11 publications

Tick-Borne Encephalitis Virus: An Emerging Ancient Zoonosis?

Tick-Borne Encephalitis Virus: An Emerging Ancient Zoonosis?

TBEV Subtyping in Terms of Genetic Distance

Relevance of Parasitological Research in the South of the Russian Far East

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