Comparative analysis of immune function, hemorheological alterations and prognosis in colorectal cancer patients with different traditional Chinese medicine syndromes

Wang, Chengyang; Ding, Huanzhang; Tang, Xianfeng; Li, Zegeng

doi:10.3233/cbm-170805

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…In this study, the multivariate analysis confirmed TCM syndrome as an independent prognostic factor, and the KM analysis indicated that HBV-related HCC patients with TCM excess syndrome had the longest median survival time. Previous studies indicated that cancer patients with TCM deficiency syndrome have lower immune function and shorter survival time, while cancer patients with excess syndrome have better immune function and longer survival time, which supports the finding of our study [ 9 ]. Also, TCM can promote the antitumor effect by restoring immunosurveillance, including upregulating immunostimulatory factors and downregulating immunosuppressive factors [ 25 ].…”

Section: Discussionsupporting

confidence: 92%

“…In TCM theory, TCM syndrome consists of a series of specific clinical symptoms, but there is no unified diagnostic standard of TCM syndromes currently. In our study, TCM syndromes of HBV-related HCC patients were determined on the basis of the “guidelines for diagnosis and treatment of primary liver cancer in China,” [ 8 ] the standard of excess and deficiency syndromes in “ Diagnostics of TCM ” (a textbook for universities and colleges of TCM in China), and a previous study [ 9 ]. In our study, TCM syndromes were classified into three types: excess syndrome, deficiency syndrome, and syndrome of intermingled deficiency and excess patterns.…”

Section: Methodsmentioning

confidence: 99%

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Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology

Wei

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. In traditional Chinese medicine (TCM), TCM syndrome is a key guideline, and Chinese materia medicas are widely used to treat hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC) according to different TCM syndromes. However, the prognostic value of TCM syndromes in HBV-related HCC patients has never been studied. Methods. A retrospective cohort of HBV-related HCC patients at Shenzhen Traditional Chinese Medicine Hospital from December 2005 to October 2017 was analyzed. The prognostic value of TCM syndromes in HBV-related HCC patients was assessed by Kaplan–Meier survival curves and Cox analysis, and the TCM syndrome with the best prognosis of HBV-related HCC patients was determined. To further study the relevant mechanisms, key Chinese materia medicas (KCMMs) for the TCM syndrome with the best prognosis were summarized, and network pharmacology was also performed. Results. A total of 207 HBV-related HCC patients were included in this research, and we found that HBV-related HCC patients with TCM excess syndrome had better OS. Then, a total of eight KCMMs for TCM excess syndrome were identified, whose crucial ingredients included quercetin, beta-sitosterol, kaempferol, luteolin, and XH-14, and KCMMs could play a therapeutic role through MAPK, JAK-STAT, Wnt, Hippo, and other pathways. Moreover, TP53, SRC, STAT3, MAPK3, PIK3R1, HRAS, VEGFA, HSP90AA1, EGFR, and JAK2 were determined as the key targets. Conclusion. We propose a new research method of “prognosis of TCM syndromes-KCMMs-network pharmacology” to reveal the prognostic value of TCM syndromes and the potential mechanism by which TCM syndromes affect prognosis.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology

Wei

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The antitumor treatment of Traditional Chinese Medicine (TCM) has undergone thousands of years of clinical practice, and its efficacy is unquestionable. It is an important part of comprehensive treatment of malignant tumors [ 4 – 6 ]. Colorectal cancer (CRC) is the second most common malignant tumor in women and the third most common one in men which has high morbidity and mortality [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Sang

Qiu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the major diseases currently endangering human health. CRC (colorectal cancer) has a significant upward trend in morbidity and mortality in many parts of the world. Technological advances have not yet brought about a breakthrough in the efficacy of CRC. The development of colon cancer is closely related to gut microbiota imbalance. According to more than 60 years of clinical practice, Professor Zhongying Zhou first proposed the pathogenesis theory of “cancerous toxin” in the 1990s and believed that cancerous toxin was a key pathogenesis of tumor development. Under the guidance of the theory of cancerous toxin, combined with clinical practice, Professor Zhou created an effective anticancer Chinese herbal compound, Jiedu Xiaoai Prescription. This paper summarizes recent hotspots related to gut microbiota and the occurrence, development, and prevention of colon cancer at home and abroad. The relationship between gut microbiota and cancerous toxin theory is proposed, and the feasibility of further studying the biological basis of cancerous toxin pathogenesis theory from the perspective of gut microbiota is pointed out.

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“…Currently, surgical resection is still the only curative treatment for CRC patients. Nevertheless, due to its occult onset, most CRC patients are diagnosed in advanced stages when surgery is unavailable [4]. Another issue is that major complications occur on up to 15% patients, and postoperative recurrence and metastasis are quite common [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, due to its occult onset, most CRC patients are diagnosed in advanced stages when surgery is unavailable [4]. Another issue is that major complications occur on up to 15% patients, and postoperative recurrence and metastasis are quite common [4,5]. Neoadjuvant and adjuvant chemoradiotherapy is now generally accepted standard treatment for locally advanced CRC, with the aim of reducing recurrence and metastasis [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology

Lin

Liang

Peng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Colorectal cancer (CRC) is now the second most deadly cancer globally. Chinese herbal medicine (CHM) plays an indispensable role in CRC treatment in China. However, the core herbs (the CHs) in the treatment of CRC and their underlying therapeutic mechanisms remain unclear. This study aims to uncovering the CHs and their mechanisms of action of CRC treatment, applying data mining and network pharmacology approach. First, CHM prescriptions treating CRC were collected from clinical studies from the Chinese National Knowledge Infrastructure (CNKI) and MEDLINE databases, and the CHs were identified through data mining. Then, the bioactive compounds and the corresponding putative targets of the CHs were obtained from three traditional Chinese medicine (TCM) databases. CRC related targets were acquired from three disease databases; the overlapping targets between the CHs and CRC were identified as the therapeutic targets. Subsequently, functional enrichment analysis was performed to elucidate the mechanisms of the CHs on CRC. Moreover, networks were constructed to screen the major bioactive compounds and therapeutic targets. Finally, prognostic values of the major target genes were evaluated by survival analysis, and molecular docking simulation was performed to assess the binding affinity of key targets and major bioactive compounds. It came out that 10 the CHs from 113 prescriptions and 190 bioactive compounds with 118 therapeutic targets were identified. The therapeutic targets were mainly enriched in the biological progress of transcription, apoptosis, and response to cytokine. Various cancer-associated signaling pathways, including microRNAs, TNF, apoptosis, PI3K-Akt, and p53, were involved. Furthermore, 15 major bioactive compounds and five key target genes (VEGFA, CASP3, MYC, CYP1Y1, and NFKB1) with prognostic significance were identified. Additionally, most major bioactive compounds might bind firmly to the key target proteins. This study provided an overview of the anti-CRC mechanisms of the CHs, which might refer to the regulation of apoptosis, transcription, and inflammation.

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Comparative analysis of immune function, hemorheological alterations and prognosis in colorectal cancer patients with different traditional Chinese medicine syndromes

Abstract: Taken together, we conclude that patients with TCM deficiency syndrome has lower immune function and poorer prognosis while patients with TCM excess syndrome has higher immune function and better prognosis of CRC.

Cited by 12 publications

References 23 publications

Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology

Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology

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