Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure

Exosomal miRNAs species in the blood of small cell and non-small cell lung cancer patients

“…The study by Zhao et al, (2016) demonstrated higher complexity of miRNA profiles in bovine sera than in sera-derived exosomes [ 69 ] with several miRNA species exclusive for each compartment. Similar results were demonstrated by Lim et al, (2017) [ 70 ] who demonstrated difference in miRNA profiles between cells and exosomes harvested from cell medium. Hence, in the future, we could see a higher number of matches between datasets once additional lung cancer-related studies that are based on blood-derived exosomes become available.…”

The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications

“…EV miRNA content can also be modified by external factors, including hypoxia [ 42 ], carcinogens such as asbestos [ 43 ] or toluene [ 44 ], and infection with oncogenic viruses [ 45 , 46 , 47 ]. As with RBPs, these factors can alter EV miRNA content in ways that may promote or inhibit tumorigenesis.…”

Frontiers in Toxicogenomics in the Twenty-First Century—the Grand Challenge: To Understand How the Genome and Epigenome Interact with the Toxic Environment at the Single-Cell, Whole-Organism, and Multi-Generational Level

“…Several studies have characterized exosome cargoes that correlate with different brain diseases (Dorsett et al, 2017 ; Levy, 2017 ; Selmaj et al, 2017 ). There have been very few studies linking toxicant exposures to changes in exosomes, but a recent study did a comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure (Lim et al, 2017 ). We believe that the role that toxicants have on exosome cargoes for endocrine signaling throughout the body is an important emergent field in toxicology research.…”