2019
DOI: 10.21470/1678-9741-2018-0243
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Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies – A Randomized Study

Abstract: Objective The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol ® ) and with intermittent hypothermic blood solution. Methods Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine … Show more

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Cited by 5 publications
(5 citation statements)
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“…A single-dose HTK perfusion regimen is becoming more frequent in technically complex heart surgeries requiring a long AC. The median AC time in this study cohort was above 80 min, which is consistent with previous studies where AC time exceeded 60 min [5,14] . This retrospective study aimed to investigate the clinical influence of high dosage HTK perfusion on neonatal patients.…”
Section: Discussionsupporting
confidence: 88%
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“…A single-dose HTK perfusion regimen is becoming more frequent in technically complex heart surgeries requiring a long AC. The median AC time in this study cohort was above 80 min, which is consistent with previous studies where AC time exceeded 60 min [5,14] . This retrospective study aimed to investigate the clinical influence of high dosage HTK perfusion on neonatal patients.…”
Section: Discussionsupporting
confidence: 88%
“…The median AC time in this study cohort was above 80 min, which is consistent with previous studies where AC time exceeded 60 min. [ 5 , 14 ] This retrospective study aimed to investigate the clinical influence of high dosage HTK perfusion on neonatal patients. The HTK dosage in the high-dose group was significantly higher than in previous studies.…”
Section: Discussionmentioning
confidence: 99%
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“…In group A, the mean ejection fraction after the valvular replacement was higher compared to group B (53.17 ± 7.73 compared with 49.06 ± 7.170) [ 89 ]. Other recent surveys did not find statistical differences in myocardial damage (Troponin-I, CK-MB) comparing the cardioplegic solution in question to others that were renowned [ 90 , 91 , 92 , 93 ].…”
Section: Bretschneidermentioning
confidence: 88%