Comparative analysis of non-motor symptoms in patients with Parkinson’s Disease and atypical parkinsonisms

Grażyńska, Anna; Urbaś, Weronika; Antoniuk, S.A.; Adamczewska, K.; Bień, Martyna; Chmiela, Tomasz; Siuda, Joanna

doi:10.1016/j.clineuro.2020.106088

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…Nonetheless, apart from motor symptoms, non-motor symptoms (NMS) worsen PD and AP patients’ quality of life equally as much, and their specific origin is particularly complex. Dopaminergic pathways dysfunction may affect the occurrence of cognitive disorders, sleep disorders (e.g., RLS), or autonomic disorders (e.g., urinary symptoms) [ 9 ]. NMS can be iatrogenic, caused by treatment with dopamine agonists which may, in turn, cause orthostatic hypotension, impulse control disorders, or even hallucinations [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review

et al. 2021

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Background and Objectives: A growing number of studies correlated higher levels of serum uric acid (UA) with both: lower risk of Parkinson’s Disease (PD) occurrence and slower progression of the disease. Similar conclusions were made where studies correlated UA with atypical Parkinsonisms (AP) progression. A few researchers have studied the issue of the influence of serum UA on the occurrence of non-motor symptoms (NMS) in PD and AP. Our systematic review is the first review completely dedicated to this matter. Materials and Methods: A comprehensive evaluation of the literature was performed to review the relationship between UA and NMS in PD and AP. The systematic review was conducted according to PRISMA Statement guidelines. The following databases were searched starting in April 2021: MEDLINE via PubMed, Embase, and Scopus. During the research, the following filters were used: >2010, articles in English, concerning humans. The study was not registered and received no external funding. Results: Seven articles meeting all inclusion criteria were included in this study. Collectively, data on 1104 patients were analyzed. A correlation between serum UA concentration and a few NMS types has been provided by the analyzed studies. In four papers, sleep disorders and fatigue were related to UA for both advanced and early PD. Other commonly appearing NMS domains were Attention/memory (4 studies), Depression/anxiety (3 studies), Cardiovascular (3 studies), Gastrointestinal (1 study), Perceptual (1 study), and Miscellaneous (1 study). For AP, no significant correlation between UA and worsening of NMS has been found. Conclusions: Based on the analyzed studies, a correlation between serum UA level and the occurrence and worsening of NMS in PD and APs cannot be definitively determined. Large-scale studies with a more diverse patient population and with more accurate methods of NMS assessment in Parkinsonism are needed.

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Section: Introductionmentioning

confidence: 99%

The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review

et al. 2021

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“…It has been estimated that autonomic disorders may be present in about 60% of patients with α-synucleinopathies, while only in 30% of patients with PSP or CBS. 10 …”

Section: Discussionmentioning

confidence: 99%

“…The most common autonomic symptoms include constipation, micturition disorders, excessive perspiration, dysfunctions of sphincters and orthostatic hypotension. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

If Not Insulin Resistance so What? – Comparison of Fasting Glycemia in Idiopathic Parkinson’s Disease and Atypical Parkinsonism

Chmiela¹,

Węgrzynek²,

Kasprzyk³

et al. 2022

DMSO

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Background Parkinson’s disease (PD) is a synucleinopathy, which presents dysautonomia, as its common non-motor symptom. Some research suggests the existing interplay between the autonomic nervous system dysfunction and glucose metabolism dysregulation in PD. Objective To determine the prevalence of metabolic disorders with particular emphasis on glucose metabolism in patients with PD and atypical parkinsonism (AP). Patients and Methods A retrospective study was performed by analyzing 461 clinical data of consecutive patients diagnosed with PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) hospitalized from 2019 to 2021 in the authors’ institution. The study group included 350 patients (303 PD, 14 MSA, 33 PSP), aged 65.8 ± 9.7 years (42% were female). Laboratory results (fasting glycemia, lipid parameters, TSH, homocysteine and vitamin D3 levels) were collected. The patient’s clinical condition was assessed in III part of Unified Parkinson’s Disease Rating Scale (UPDRS p. III), Hoehn–Yahr scale, Mini Mental State Examination (MMSE) and Beck Depression Inventory (BDI). Results Impaired fasting glycemia (IGF) was more prevalent in PD than in the PSP (43.43% vs 18.18%; p = 0.043). Similarly, PD presented a higher level of fasting glycemia (102.4 ± 16.7 mg/dl vs 92.2 ± 16.1mg/dl; p = 0.042). According to lipid parameters, patients with PD showed lower LDL cholesterol (92.3 ± 44.3mg/dl vs 119 ± 61.0mg/dl; p = 0.016) and lower BMI compared to patients with PSP (26.1 ± 4.0kg/m 2 vs 29.3 ± 4.4 kg/m 2 ; p = 0.024), but there were no statistically significant differences in triglycerides (TG) and HDL cholesterol levels. Males with PD presented greater frequency of IFG (35.05% vs 50.6%; p = 0.042), higher fasting glycemia (99.1 ± 14.3mg/dl vs 103.7 ± 14.7mg/dl; p = 0.006), lower total cholesterol, HDL cholesterol, and BMI compared to women with PD. Conclusion Our investigation supports an association between synucleinopathies and glucose metabolism dysregulation.

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“…It occurs with the degeneration and/or loss of cells that secrete dopamine as a result of damage in the substantia nigra region of the brain. [3,4] As the disease progresses and dopamine in the brain decreases, the symptoms of PD become more pronounced.…”

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confidence: 99%

“…[5] Neuropathological factors of Parkinson's disease; vascular diseases, previous brain infections, some medications, atherosclerosis, familial causes, trauma, poisoning, toxins, tumors, and consequently loss of neurons and neurotransmitters. [3,4] Researchers are working on ways to stop or slow the loss of these dopamine-producing cells. There is currently no cure for PD but medications can help control the symptoms.…”

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confidence: 99%

Parkinson’s Disease: Mechanisms, Pathogenesis, Animal Models and Tests

Ünal¹

2021

JEB Med Sci

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Parkinsonism is a progressive brain disorder characterized by tremor, rigidity, bradykinesia, akinesia, and loss of postural reflexes. The pathologic feature of Parkinson's disease, basically known as a movement disorder, is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, one of the main components of basal ganglia, and accumulation of alpha-synuclein called intracellular protein aggregates (Lewy bodies) in surviving neurons. There are several reasons for the disease, among which genetic factors and various toxins are noted. Parkinson's disease is the second most common neurodegenerative disease in the world and in our country that occurs in association with advanced age with the increase in life expectancy. In this review, the formation mechanism of the disease, Parkinson's tests, and methods used in experimental modeling will be discussed.

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Comparative analysis of non-motor symptoms in patients with Parkinson’s Disease and atypical parkinsonisms

Cited by 14 publications

References 40 publications

The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review

The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review

If Not Insulin Resistance so What? – Comparison of Fasting Glycemia in Idiopathic Parkinson’s Disease and Atypical Parkinsonism

Parkinson’s Disease: Mechanisms, Pathogenesis, Animal Models and Tests

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