Comparative Analysis of Oct and Oct Angiography Characteristics in Early Diabetic Retinopathy

Abstract

Purpose: To assess the quantitative characteristics of optical coherence tomography (OCT) and OCT angiography (OCTA) for the objective detection of early diabetic retinopathy (DR).Methods: This was a retrospective and cross-sectional study, which was carried out at a tertiary academic practice with a subspecialty. Twenty control participants, 15 people with diabetics without retinopathy (NoDR), and 22 people with mild nonproliferative diabetic retinopathy (NPDR) were included in this study. Quantitative OCT characteristics were derived from the photoreceptor hyperreflective bands, i.e., inner segment ellipsoid (ISe) and retinal pigment epithelium (RPE). OCTA characteristics, including vessel diameter index (VDI), vessel perimeter index (VPI), and vessel skeleton density (VSD), were evaluated.Results: Quantitative OCT analysis indicated that the ISe intensity was significantly trending downward with DR advancement. Comparative OCTA revealed VDI, VPI, and VSD as the most sensitive characteristics of DR. Correlation analysis of OCT and OCTA characteristics revealed weak variable correlation between the two imaging modalities.Conclusion: Quantitative OCT and OCTA analyses revealed photoreceptor and vascular distortions in early DR. Comparative analysis revealed that the OCT intensity ratio, ISe/RPE, has the best sensitivity for early DR detection. Weak variable correlation of the OCT and OCTA characteristics suggests that OCT and OCTA are providing supplementary information for DR detection and classification.

Adaptive vessel tracing and segmentation in OCT enables the robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice

“…By providing three-dimensional imaging capability, optical coherence tomography (OCT) has extensively been used for the clinical management of eye diseases [ 30 – 35 ]. Recently, axial projection OCT has been used to quantify retinal blood vessel diameter and WLR [ 36 – 38 ].…”

Adaptive vessel tracing and segmentation in OCT enables robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice

“…By providing three-dimensional imaging capability, optical coherence tomography (OCT) has extensively been used for the clinical management of eye diseases [30][31][32][33][34][35]. Recently, axial projection OCT has been used to quantify retinal blood vessel diameter and WLR [36][37][38].…”