Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats

AL-Thamarani, Sadeq; Gad, Shadeed; Abdel Fattah, Islam Omar; Hammadi, Sami H.; Hammady, Taha M.

doi:10.1016/j.tice.2024.102394

Tissue and Cell

2024

DOI: 10.1016/j.tice.2024.102394

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Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats

Sadeq AL-Thamarani,

Shadeed Gad,

Islam Omar Abdel Fattah

et al.

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2024

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The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders

van Staden,

Gerber,

Lemmer

2024

Pharmaceutics

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The prevalence of female reproductive system disorders is increasing, especially among women of reproductive age, significantly impacting their quality of life and overall health. Managing these diseases effectively is challenging due to the complex nature of the female reproductive system, characterized by dynamic physiological environments and intricate anatomical structures. Innovative drug delivery approaches are necessary to facilitate the precise regulation and manipulation of biological tissues. Nanotechnology is increasingly considered to manage reproductive system disorders, for example, nanomaterial imaging allows for early detection and enhances diagnostic precision to determine disease severity and progression. Additionally, nano drug delivery systems are gaining attention for their ability to target the reproductive system successfully, thereby increasing therapeutic efficacy and decreasing side effects. This comprehensive review outlines the anatomy of the female upper genital tract by highlighting the complex mucosal barriers and their impact on systemic and local drug delivery. Advances in nano drug delivery are described for their sustainable therapeutic action and increased biocompatibility to highlight the potential of nano drug delivery strategies in managing female upper genital tract disorders.

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The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders

van Staden,

Gerber,

Lemmer

2024

Pharmaceutics

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Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats

Cited by 1 publication

References 39 publications

The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders

The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders

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