Comparative Analysis of Pathobiochemical Changes in Major Depression and Post-Traumatic Stress Disorder

Ступин, К.Н.; Zenko, Mikhail Yu.; Рыбникова, Е. А.

doi:10.1134/s0006297921060109

Cited by 5 publications

(3 citation statements)

References 81 publications

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“…If a child experiences trauma, the risk of the child developing a major depressive disorder or post-traumatic stress disorder (PTSD) later in life is equal (60). If, on the other hand, the trauma occurs during adolescence, the risk of developing PTSD is greater than the risk of developing depression (68,69).…”

Section: The Stress Response Of the Hpa Axis And Cortisolmentioning

confidence: 99%

Association of Post-Traumatic Stress Disorder (PTSD) in Children and HPA Axis Regulation

Chinchaipong

2022

Int J Sci Healthcare Res

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Over the past decades, numerous findings have shown that exposure to stress or trauma during the critical period of early development can elicit adverse impacts on the psychological processes and physiological functioning of the body. Precisely, early life stress is associated with a greater risk of developing mental disorders or physical conditions later in life. Accordingly, early life adversity may alter children’s regulation of secretion of neurobiological substrates, as well as influence the sensitivity of their response to stimuli such as stressors. Children who encountered a traumatic event, such as natural disasters, sexual or physical abuse, may develop Post-traumatic stress disorder (PTSD), which may in turn disturbed the development of HPA axis and other neuroendocrinal systems which regulate the body’s response to stressors. However, the degree and manner of which childhood stress impacts the regulation of the HPA axis remain unclear and conflicted. Several studies have reported that abused children demonstrated substantially higher morning cortisol levels, which is regulated by the HPA axis, than non abused children. Other studies, however, have shown contradicting results Keywords: Adolescent, childhood trauma, corticotropins, cortisol, HPA axis regulation, post-traumatic stress disorder.

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Section: The Stress Response Of the Hpa Axis And Cortisolmentioning

confidence: 99%

Association of Post-Traumatic Stress Disorder (PTSD) in Children and HPA Axis Regulation

Chinchaipong

2022

Int J Sci Healthcare Res

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“…Рыбникова Елена Александровна, проводит исследование патогенетических нейроэндокринных механизмов депрессии и посттравматического стрессового расстройства [34].…”

Section: Introductionunclassified

Saint Petersburg Branch of the Scientific Council of the Russian Academy of Sciences on the Methodology of Artificial Intelligence and Cognitive Research in 2022

Sergeev

2023

Ergodesign

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The paper considers the history of creation, composition and activities of the St. Petersburg branch of the Scientific Council on the Methodology of Artificial Intelligence and Cognitive Research under the Presidium of the Russian Academy of Sciences. A pronounced orientation to practice of the department members is shown, which is associated with the predominance of engineering and natural science scientists in its membership. The Council stimulates work related to the interdisciplinary synthesis and convergence of the humanities and natural sciences in solving the problem of artificial intelligence.

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“…Depression is a complex and heterogeneous disease, and its etiopathogenesis involves many factors at different psychological, biological, genetic and social levels [8]. Despite the great medical and social importance of MD, there is no clear concept behind its causes and the mechanism of its development.…”

Section: Introductionmentioning

confidence: 99%

Ketamine—New Possibilities in the Treatment of Depression: A Narrative Review

Kowalczyk¹,

Kowalczyk

Kwiatkowski

et al. 2021

Life

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The SARS-CoV-2 coronavirus epidemic has led to an increase in the number of people with depression. Symptoms related to the mental sphere (mainly depression and anxiety) may be experienced by one third of the worldwide population. This entails the need for the effective and rapid treatment of depressive episodes. An effective drug seems to be s-ketamine, which was accepted in March 2019 by the Food and Drug Administration (FDA) for the treatment of drug-resistant depression. This drug provides a quick antidepressant effect with maximum effectiveness achieved after 24 h. It also appears to reduce the occurrence of suicidal thoughts. However, research into undesirable effects, especially in groups of people susceptible to psychotic episodes or those who use alcohol or psychoactive substances, is necessary.

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Comparative Analysis of Pathobiochemical Changes in Major Depression and Post-Traumatic Stress Disorder

Cited by 5 publications

References 81 publications

Association of Post-Traumatic Stress Disorder (PTSD) in Children and HPA Axis Regulation

Association of Post-Traumatic Stress Disorder (PTSD) in Children and HPA Axis Regulation

Saint Petersburg Branch of the Scientific Council of the Russian Academy of Sciences on the Methodology of Artificial Intelligence and Cognitive Research in 2022

Ketamine—New Possibilities in the Treatment of Depression: A Narrative Review

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