Comparative analysis of phytochemical constituents present in various parts of Aegle marmelos

Nirupama, GS; Padmasri, G; Ramesh, RV; Vasanthi, M

doi:10.1016/s2222-1808(12)60263-1

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…Marmelosin derived from the pulp is given a laxative and diuretic effect. Stem bark and root of aqueous extracts have similar phytochemical compounds (Nirupama et al, 2012). In large doses, it lowers the rate of respiration, depresses heart action and causes sleepiness.…”

Section: Medicinal Uses Of Baelmentioning

confidence: 99%

Bael (Aegle marmelos Correa) products processing: A review

Singh¹,

Sharma²,

Kaushal³

et al. 2014

Afr. J. Food Sci.

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Section: Medicinal Uses Of Baelmentioning

confidence: 99%

Bael (Aegle marmelos Correa) products processing: A review

Singh¹,

Sharma²,

Kaushal³

et al. 2014

Afr. J. Food Sci.

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“…Various parts of the Aegle marmelos such as root, bark, leaves and fruits are used in Indian system of medicine for its numerous medicinal properties like antioxidant, antibacterial, antifungal, antidiarrheal, antidiabetic, antiproliferative, cytoprotective, hepatoprotective, fertility booster, analgesic, antiarthritis, contractile, antihyperlipidemic, cardioprotective, radioprotective, anticancer, antiviral, antiulcer, immunomodulatory and wound healing properties 17 , 18 . The phytochemical studies have shown that the Aegle marmelos fruit contains several classes of phytochemical compounds like carotenoids, phenolics, flavonoids, alkaloids, tannins, terpenoids, coumarins, steroids, saponins, lignins, phlobatannins, inulin and cardiac glycosides 19 , 20 . The flavonoids, tannins and phenolic compounds, that act as a primary antioxidant and free radical scavengers are found to be maximum in the alcoholic extract of the fruit pulp 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

Akhouri

Kumari

Kumar

2020

Sci Rep

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Breast cancer is among most common form of cancer worldwide. It is also the major cause of death in female cancer patient around the world. Despite various therapeutic measures, it remains associated with high mortality rate. Aegle marmelos (L.) Correa has been extensively used in Indian medicine system Ayurveda, due to its various medicinal properties. However, there are very limited reports regarding its anticancer activity. Thus, the present research work has been aimed to study the anticancer activity of Aegle marmelos fruit extract on 7,12-dimethylbenz(a)anthracene (DMBA) induced breast cancer in rats. Female Charles Foster rats, 55–60 days old weighing around (150 ± 10 g) were used for the study and were induced DMBA (20 mg/mL dissolved in Olive oil) orally. After the development of breast tumors (about 0.5 cm), the rats were treated with Aegle marmelos ethanolic fruit pulp extract (200 mg/kg b.w./day) orally for 5 weeks and then volume of tumor was measured. Aegle marmelos treatment showed significantly reduced mammary tumor volume (P < 0.05), along with significant reduction (P < 0.0001) in the different serum biomarkers such as TNF-α level, serum malondialdehyde (MDA) level and glucose levels. Significant (P < 0.0001) improvement in both, the kidney and liver serum biomarker parameters were also observed after the treatment with Aegle marmelos ethanolic fruit pulp extract. From the entire study, taking everything into account it can be interpreted that Aegle marmelos ethanolic fruit pulp extract possesses anti-proliferative activity by suppressing the progression of breast tumors in rat model. The plant extract also possesses hepato-renal protective effect. Hence, it can be targeted as novel and safe anti-cancer drug against breast cancer.

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“…There are many active compounds which are chemically very active (Nirupama et al, 2012). A large number of biologically active compounds are found in the plant such as various organic acids including oxalic, tartaric, malic and ascorbic acid, various phenolics in the fruit as chlorogenic acid, ellagic acid, ferulic acid, gallic acid, protocatechuic acid and quercetin.…”

Section: Phyto-constituents Of Aegle Marmelos (L) Corrmentioning

confidence: 99%

“…Volume 3(4) [51][52][53][54][55][56] of the common ailments of humans (Kumari et al, 2020). All the parts of this plant like fruit, leaves, bark, stem, roots are used in the treatment of different diseases (Baliga et al, 2011, Nirupama et al, 2012. Plants which are rich sources of ecologically developed secondary metabolites are often used as potent remedies for different ailments (Ganesh et al, 2011).…”

Section: Introductionmentioning

confidence: 99%