Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis

Abstract

There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive and specific oxidative stress biomarker that could best reflect the existence of one of these disease entities. Methods: Forty patients with PsO and forty patients with AD were consecutively included in this cross-sectional study. Parameters of redox homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) and advanced oxidation protein products (AOPP)] and antioxidants [catalase (CAT) and superoxide dismutase (SOD)] were determined. Results: There was no difference in oxidative stress biomarkers between the PsO and AD group, except for higher CAT activity in the AD group (p < 0.001). Among all examined redox homeostasis biomarkers, ROC analysis showed that only CAT exhibited good diagnostic accuracy (AUC = 0.719) in the discrimination of patients with PsO vs. AD, with 0.436 U/L as the cut-off value of CAT activity. Conclusions: The CAT exhibited good diagnostic accuracy in the discrimination of patients with AD from those with PsO. The obtained results could suggest the importance of the use of antioxidants as a potential therapeutic strategy in the treatment of these two skin inflammatory diseases.

Effects of Different Therapeutic Approaches on Redox Balance in Psoriatic Patients

“…Another clinical relevance of these results is potential use in diagnosis given that we also indicated a lower ability of the antioxidant defense system. Other authors also showed lower values of CAT and SOD in psoriatic patients compared to the other forms of inflammatory skin diseases [ 51 ].…”

“…Results of this study indicate a more pronounced improvement of redox status in patients treated with biologics compared to MTX. Due to reduced antioxidative capacity in patients treated with MTX, shown by us and others [ 51 ], it would be of interest to consider antioxidants as supportive therapy. The aim of the application of antioxidants, either as adjuvants or maintenance therapy, should be directed towards the increase in endogenous antioxidative capacity, especially in MTX-treated patients.…”

“…The aim of the application of antioxidants, either as adjuvants or maintenance therapy, should be directed towards the increase in endogenous antioxidative capacity, especially in MTX-treated patients. Furthermore, due to the close connection between inflammation, oxidative stress, and psoriasis, a higher intake of dietary antioxidants could be one of the first steps in the improvement of the clinical presentation of psoriatic patients [ 51 ]. Another clinical relevance of these results is potential use in diagnosis given that we also indicated a lower ability of the antioxidant defense system.…”

Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and FTO Gene Polymorphisms (rs9939609, rs1558902)

“…Hence, there is a crucial need to advocate for healthy lifestyle choices and prioritize patient education initiatives among individuals with psoriasis. Recent findings indicate the significance of incorporating antioxidant-rich foods into psoriatic patients’ diet and considering antioxidants as a potential therapeutic approach for managing inflammatory skin conditions [ 51 ]. Oxidative stress is believed to be a crucial factor in the inflammatory cascade of the pathological mechanism of psoriasis.…”

The Promising Role of Polyphenols in Skin Disorders

“…Moreover, there is sufficient evidence substantiating the advantageous effect of flavonoids in the management of psoriasis. Currently, the use of prescription medications, following a healthy lifestyle, and consuming a diet rich in antioxidants have the potential to reduce the damaging effects of oxidative stress caused by psoriasis, especially on the skin [ 184 ]. The overproliferation of keratinocytes and chronic inflammation in psoriasis are associated with increased concentrations of TNF and vascular endothelial growth factor (VEGF).…”