Comparative analysis of salivary microbiome diversity in edentulous infants and their primary care givers

Cephas, Kimberly D.; Kim, Ju-Hee; Mathai, Rose Ann; Barry, Kathleen A.; Dowd, Scot E.; Meline, Brandon S.; Swanson, Kelly S.

doi:10.1096/fasebj.25.1_supplement.1121.1

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proposed that bacteria present in the infant's oral cavity help to shape milk microbial communities via retrograde flow of bacteria from the infant's mouth to the breast and mammary ducts. This hypothesis is supported, in part, by the finding that Streptococcus species are dominant in both the infant oral cavity and human milk (Cephas et al, 2011;Hunt et al, 2011;Fernandez et al, 2013). In addition, on a compositional basis, the complex milk microbiome is notably similar to that of the infant's oral cavity.…”

Section: Origin and Importance Of Milk Microbiotamentioning

confidence: 93%

Interrogating the role of the milk microbiome in mastitis in the multi-omics era

Couvillion

Mostoller²,

Williams³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

There is growing interest in a functional understanding of milk-associated microbiota as there is ample evidence that host-associated microbial communities play an active role in host health and phenotype. Mastitis, characterized by painful inflammation of the mammary gland, is prevalent among lactating humans and agricultural animals and is associated with significant clinical and economic consequences. The etiology of mastitis is complex and polymicrobial and correlative studies have indicated alterations in milk microbial community composition. Recent evidence is beginning to suggest that a causal relationship may exist between the milk microbiota and host phenotype in mastitis. Multi-omic approaches can be leveraged to gain a mechanistic, molecular level understanding of how the milk microbiome might modulate host physiology, thereby informing strategies to prevent and ameliorate mastitis. In this paper, we review existing studies that have utilized omics approaches to investigate the role of the milk microbiome in mastitis. We also summarize the strengths and challenges associated with the different omics techniques including metagenomics, metatranscriptomics, metaproteomics, metabolomics and lipidomics and provide perspective on the integration of multiple omics technologies for a better functional understanding of the milk microbiome.

show abstract

Section: Origin and Importance Of Milk Microbiotamentioning

confidence: 93%