Comparative analysis of serum homocysteine, folic acid and Vitamin B12 levels in patients with noise-induced hearing loss

Gök, Üzeyir; Halifeoğlu, İhsan; Canatan, Halit; Yildiz, Mücahit; Gürsu, Ferit; Gur, Biray

doi:10.1016/j.anl.2003.09.001

Cited by 29 publications

(26 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies are needed to fully understand the role of Hcy and its metabolites in the cochlea. On the other hand, environmental factors include exposure to high levels of noise, ototoxic drugs or nutritional deficiencies (Gok et al, 2004; Tabuchi et al, 2011). Moreover, certain genetic factors predispose to suffer damage due to noise or ototoxic drugs, as well as, to premature aging of the hearing structures (Zhao et al, 2004; Rydzanicz et al, 2010); their identification is one of the current challenges in this field of research.…”

Section: Hearing Lossmentioning

confidence: 99%

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies.

show abstract

Section: Hearing Lossmentioning

confidence: 99%

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Amongst other possible contributing factors, homocysteine has been implicated in noise-induced hearing loss (NIHL). Gok et al demonstrated that patients with NIHL had higher serum levels of Hcy and lower serum levels of folate and vitamin B 12 as compared to normal controls [17].…”

Section: Homocysteine the Cochlea And Hearingmentioning

confidence: 99%

Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review

Bhargava

et al. 2015

Ind J Clin Biochem

View full text Add to dashboard Cite

Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.

show abstract

“…Previously, studies had shown that low folic acid and vitamin B 12 levels were associated with hearing loss. 1,2 In an editorial accompanying the Durga paper in the Annals of Internal Medicine, 3 Robert A. Dobie, M.D., of the University of California, Davis, noted that long-term folic acid supplementation might be able to reduce hearing loss by as much as 5 dB over 20 years. But he also cautioned that more research was needed to confirm the benefits of folic acid.…”

Section: Act Notesmentioning

confidence: 99%