Comparative Analysis of Serum Manganese, Zinc, Calcium, Copper and Magnesium Level in Panic Disorder Patients

Abstract

The purpose of the study was to determine the serum concentration of trace elements of panic disorder patients and to find out the relationship between trace element levels and nutritional status or socio-economic factors. The study was conducted among 54 panic disorder patients and 52 healthy volunteers. Patients were recruited from Bangabandhu Sheikh Mujib Medical University by random sampling. Serum trace element concentrations were determined by flame atomic absorption spectroscopy (for Mg, Zn, Ca, and Cu) as well as graphite furnace (for Mn). Data were analyzed by independent t test, Pearson's correlation analysis, regression analysis, and ANOVA. The serum concentration of Mn, Zn, Ca, Cu, and Mg in panic disorder patients were 0.37 +/- 0.30, 0.67 +/- 0.20, 99.91 +/- 15.15, 0.83 +/- 0.23, and 21.14 +/- 3.72 mg/L, while those were 0.4163 +/- 0.2527, 0.86 +/- 0.3, 106.6073 +/- 18.6531, 0.8514 +/- 0.3646, and 21.37 +/- 2.03 mg/L in control subjects, respectively. The serum concentration of Zn decreased significantly (p = 0.001) in patient group. But the differences of the concentration of Mn, Ca, Cu, and Mg between patient and control group were not significant (p = 0.522, p = 0.065, p = 0.800, and p = 0.712, respectively). Socio-economic data reveal that most of the patients were very poor and middle aged. Mean BMIs of the control group (23.74 +/- 2.71 kg/m(2)) and the patient group (22.62 +/- 3.74 kg/m(2)) were within the normal range (18.5-25.0 kg/m(2)). There was no significant relationship between serum zinc level and BMI of patients (r = 0.038; p = 0.809). So the decreased level of serum zinc in panic disorder patients was not because of other reasons, but rather it may provide a prognostic tool for the diagnosis and treatment of this disease.

Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels

“…Another study showed the copper concentration of lung as 1.91±1.30 mg/L and serum copper concentration as 0.85±0.19 mg/L [10]. Another study in panic disorder patients, serum copper level was found at 0.8 3±0.23 mg/L [11]. In our study, the serum copper level of workers was found statistically higher than the control group.…”

Manganese Supplementation Reduces High Glucose-induced Monocyte Adhesion to Endothelial Cells and Endothelial Dysfunction in Zucker Diabetic Fatty Rats

“…Various studies report blood concentrations of manganese between 0.15 and 7 M (7,8,26,27). Some studies have reported lower Mn 2ϩ levels in lymphocytes (7), plasma, and hair samples (8) of type 2 diabetic patients and in the heart and aorta tissue of patients with atherosclerosis when compared with those of healthy controls (9).…”

Estimation of serum zinc and copper levels patients with schizophrenia: a preliminary study

“…In the peripheral and central nervous systems they play important functional roles and are also components in nervous tissue (3)(4)(5)(6)(7)(8). Imbalances in the optimum levels of these elements may adversely affect biological processes and are associated with many psychiatric diseases including schizophrenia (9)(10)(11).…”