Comparative analysis of somatostatin analog uptake between successfully irradiated and non-irradiated meningiomas

Abstract

Objective: To evaluate whether there is a significant difference in somatostatin analog uptake in meningiomas treated or not with radiation therapy. Methods: A cross-sectional study was performed comparing measurements of somatostatin analog ( 68 Ga-DOTATATE) uptake in two independent groups of ten patients each -one consisting of patients with meningiomas previously treated with radiation therapy and another comprising patients who had never been submitted to radiation therapy. All patients underwent PET/CT and MRI scans in an interval shorter than 24 hours between exams. Results: A total of 32 meningiomas from 20 patients were analyzed, all presenting significant somatostatin analog uptake in different degrees. The uptake levels of somatostatin analog were similar between the lesions treated or not with radiation therapy, and the mean values of SUV max were 27.62 and 24.82, respectively (p=0.722). For SUV mean , the values were 16.20 and 14.82, respectively (p=0.822). Conclusion: Comparative analysis between the groups showed no significant differences in degree of somatostatin analog uptake in successfully irradiated and non-irradiated meningiomas.

Clinical value of semi-quantitative parameters in 68Ga-DOTANOC PET/CT in treatment and diagnostics of cranial meningioma in a single-center retrospective analysis

“…Before discussing the results concerning the meningiomas it is noteworthy that a higher variability between the physiological tracer uptakes in the pituitary gland with a SUVpit (SUVmax values) ranging from minimum 5.57 to maximum 52.52 (median 18.19) than in the superior sinus sagittalis with a SUVsss (SUVmax values) ranging from minimum 0.94 to maximum 4.69 (median 2.37) was found. This finding is consistent to findings reported by Campos Neto et al ( 2022 ) reporting a range from 12.75 to 32.03.…”