Comparative analysis of structural and functional characteristics of soleus muscle in rats and mongolian gerbils during gravitational unloading of different duration

Kurushin, V. A.; Glashev, M. M.; Михайлова, Е. В.; Пономарева, Е. В.; Altaeva, E. G.; Кривой, И. И.; Шенкман, Борис

doi:10.1134/s0006350910060217

Cited by 2 publications

(1 citation statement)

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“…It has been established that the size of the muscle tissue also decreases under conditions of limited action of gravity [ 70 ]. Studies of the motor sphere in weightlessness and its modeling conditions (hypokinesia, immersion and unsupported stands) showed that the hypogravitational motor syndrome caused by these conditions of weightlessness is characterized by a decrease in the mass of the muscular tissue [ 71 , 72 , 73 ], which is accompanied by a deep decrease in the contractile properties and endurance of the muscular apparatus. At the same time, the key link that is responsible for the adaptation of motor units to support unloading remained unidentified.…”

Section: Purinergic Synaptic Modulation In Experimental Muscle Mass R...mentioning

confidence: 99%

P2 Receptor Signaling in Motor Units in Muscular Dystrophy

Khairullin

Гришин

Зиганшин

2023

IJMS

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The purine signaling system is represented by purine and pyrimidine nucleotides and nucleosides that exert their effects through the adenosine, P2X and P2Y receptor families. It is known that, under physiological conditions, P2 receptors play only a minor role in modulating the functions of cells and systems; however, their role significantly increases under some pathophysiological conditions, such as stress, ischemia or hypothermia, when they can play a dominant role as a signaling molecule. The diversity of P2 receptors and their wide distribution in the body make them very attractive as a target for the pharmacological action of drugs with a new mechanism of action. The review is devoted to the involvement of P2 signaling in the development of pathologies associated with a loss of muscle mass. The contribution of adenosine triphosphate (ATP) as a signal molecule in the pathogenesis of a number of muscular dystrophies (Duchenne, Becker and limb girdle muscular dystrophy 2B) is considered. To understand the processes involving the purinergic system, the role of the ATP and P2 receptors in several models associated with skeletal muscle degradation is also discussed.

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