Comparative analysis of the immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in keratocystic odontogenic tumor, dentigerous cyst and radicular cyst

Abstract

Higher expression of VEGF and MMP-9 in KCOTs could be responsible for the aggressive behavior of this cyst that is currently considered a cystic tumor rather than a developmental cyst.

Molecular pathogenicity of 1-nonadecene and l-lactic acid, unique metabolites in radicular cysts and periapical granulomas

“…qRT-PCR setup and cycling procedures were done as previously described 59 using QuantStudio RT-PCR (Applied biosystems, USA). IL-1α, IL-1β 20 , IL-6, IL12A 3 , MMP-1 60 , MCP-1 61 , TGFβ1 29 , PDGF α 62 , and VEGF α 63 are differentially expressed in radicular cysts and correlated to epithelial cells’ proliferation. IL-1α, IL-1β 64 , IL-6 3 , MCP-1 65 , PDGFα 66 , and VEGFα 3 , 67 are differentially expressed in periapical granulomas.…”

Association of Oxidative Stress and Production of Inflammatory Mediators Matrix Metalloproteinase-9 and Interleukin 6: Systemic Events in Radicular Cysts

“…Moreover, the necrotic and degenerating cells in the interior of the cyst cavity discharge an excessive amount of molecular species, further raising the osmotic pressure of the cyst void, resulting in the flow of liquid from tissues into the cyst lumen. The outcome is an elevated intracystic pressure that can result in osteoclastic bone resorption and cyst enlargement [1][2][3]. A radicular cyst (RC) is a result of chronic inflammation in response to inflammatory mediators created from the necrosis of dental pulp [4].…”

“…A radicular cyst (RC) is a result of chronic inflammation in response to inflammatory mediators created from the necrosis of dental pulp [4]. According to Khot et al, RCs "derive their epithelial lining from the proliferation of small odontogenic epithelial residues within the periodontal ligament," which contributes to the progression of the lesion [2]. The regulation of extracellular matrix synthesis and degradation is a vital function of metalloproteases (MMPs), which are also involved in embryogenesis, ovulation, development of nerve tissue, vessel formation, apoptosis, and monitoring of various inflammatory mediators, including cytokine cleavage and activation of mediators and defensins.…”