Comparative analysis of the main medicinal substances and applications of Echium vulgare L. and Echium plantagineum L.: A review

Wang, Wu; Jin, Ju; Xu, Huifeng; Shi, Yanling; Boersch, Mark; Yin, Yuhe

doi:10.1016/j.jep.2021.114894

Cited by 14 publications

(12 citation statements)

References 80 publications

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“…5−9 Of these classes, naphthoquinones have a well-reported range of biological activities including anxiolytic, 10−13 antioxidant, 14 anti-inflammatory, 15 antibacterial, 16 and antiviral 17 effects. Furthermore, numerous common flavonoids, pyrrolizidine alkaloids, and other phenolic substances are found in bee honey produced from the plant, 4,6,8,9 and the seed oil is reported to produce an abundance of the Δ 6 -unsaturated C 18 fatty acids γ-linolenic acid and stearidonic acid, which are known to improve vascular function in humans. 18 In this study, preliminary analysis of HPLC fractions via Q-TOF MS and NMR spectroscopy revealed E. plantagineum leaf extracts (derived from material collected in 2016 from Young, New South Wales, Australia) contained various phenolic compounds, and the literature indicated that E. plantagineum…”

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confidence: 68%

“…In this study, preliminary analysis of HPLC fractions via Q-TOF MS and NMR spectroscopy revealed E. plantagineum leaf extracts (derived from material collected in 2016 from Young, New South Wales, Australia) contained various phenolic compounds, and the literature indicated that E. plantagineum might be a promising source of phenolic compounds, with potentially significant biological activities. , Herein, are reported the isolation, structure elucidation, and cytotoxic screening data against three cancer cell lines and a normal human cell line for a new aryl dihydronaphthalene lignan, echiumin E ( 1 ), two known aryl dihydronaphthalene lignans ( 3 and 4 ), and the commonly encountered phenolic compound rosmarinic acid ( 5 ), isolated for the first time from E. plantagineum .…”

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confidence: 91%

“…might be a promising source of phenolic compounds, with potentially significant biological activities. 9,19 Herein, are reported the isolation, structure elucidation, and cytotoxic screening data against three cancer cell lines and a normal human cell line for a new aryl dihydronaphthalene lignan, echiumin E (1), two known aryl dihydronaphthalene lignans (3 and 4), and the commonly encountered phenolic compound rosmarinic acid (5), isolated for the first time from E. plantagineum.…”

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confidence: 99%

“…Throughout the Mediterranean region, many species of Echium have been reported as folk medicines in wound healing or cardiovascular disease . Current published research on phytochemicals from Echium species has focused largely on the toxic pyrrolizidine alkaloids and on other constituents, such as naphthoquinones, flavonoids, and phenolic acids. − Of these classes, naphthoquinones have a well-reported range of biological activities including anxiolytic, − antioxidant, anti-inflammatory, antibacterial, and antiviral effects. Furthermore, numerous common flavonoids, pyrrolizidine alkaloids, and other phenolic substances are found in bee honey produced from the plant, ,,, and the seed oil is reported to produce an abundance of the Δ 6 -unsaturated C 18 fatty acids γ-linolenic acid and stearidonic acid, which are known to improve vascular function in humans …”

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confidence: 99%

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Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson’s Curse (Echium plantagineum)

et al. 2022

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A new aryl dihydronaphthalene lignan, echiumin E (1), and four known compounds, echiumin A, globoidnan A, (−)-rabdosiin, and rosmarinic acid (2–5), were isolated from the Australian invasive plant Echium plantagineum (Paterson’s curse) for the first time. Echiumin E (1) was characterized by 1D/2D NMR spectroscopy and MS spectrometry, with its absolute configuration assigned through comparison of experimental and TDDFT-calculated ECD data. Echiumin E (1) along with compounds 3–5 were screened in vitro against three cancer cell lines (SH-SY5Y, HeLa, and PC-3) and a prostate stromal (normal) cell line (WPMY-1) using a resazurin reduction assay. Echiumin E (1) was found to be active toward HeLa cells (IC50 0.21 μM).

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confidence: 68%

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confidence: 91%

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confidence: 99%

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confidence: 99%

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Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson’s Curse (Echium plantagineum)

et al. 2022

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“…Pharmacological activity of Echium include antimicrobial, antitumor, antiviral, and anti-inflammatory effects, mostly derived from shikonins found in the root (Wang et al. 2022 ). Seeds are also an important source of alpha-linolenic acid used in dietary supplements (Kitessa et al.…”

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confidence: 99%

The complete plastome of Echium plantagineum L. (Boraginaceae), the first chloroplast genome belonging to the Echium genus

Leonardo

Crespo

Capelo

et al. 2022

Mitochondrial DNA Part B

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Besides being a common weed, the presence of Echium plantagineum L. in food and feed commodities can represent a safety hazard due to their content in pyrrolizidine alkaloids. In this study, the complete chloroplast of E. plantagineum isolate BPTPS251 is described, being the first available plastome from an isolate belonging to the Echium genus. The chloroplast genome is 149,776 bp in length with 37.5% GC content, displaying a quadripartite structure that contains a pair of inverted repeats regions (25,754 bp each), separated by a large single-copy (80,978 bp) and a small single-copy (17,290 bp) regions. A total of 131 genes were predicted, including 37 tRNA genes, 8 rRNA genes, and 86 protein-coding genes. The phylogenetic analysis confirmed the placement of E. plantagineum under the Boraginaceae family, belonging to the Boraginales order. This study will contribute to conservation, phylogenetic, and evolutionary studies, as well as DNA barcoding applications for food and feed safety purposes.

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Phytochemical profile of petals from black Dahlia pinnata by flow injection analysis–electrospray ionization–Fourier transform ion cyclotron resonance mass spectrometry

Granados‐Balbuena,

Díaz‐Pacheco,

García‐Meza

et al. 2023

Phytochemical Analysis

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IntroductionDahlia pinnata Cav. is a flower native to Mexico that has many applications; in particular, its petals have been used for ornamental, food, and medicinal purposes, for example to treat skin rashes and skin cracks. It has been reported that the medicinal properties of plants are generally related to the phytochemical constituents they possess. However, there are few studies on black D. pinnata.ObjectivesThe present study was aimed at qualitatively and quantitatively determining the phytochemical profile of petals from black D. pinnata.MethodologyPhytochemicals from Dahlia petals were extracted by consecutive maceration (hexane, dichloromethane, and methanol); then, the extracts were analyzed through colorimetric assays and UV–Vis spectroscopy for qualitative identification and quantification of phytochemical compounds, respectively. The methanolic extract was analyzed by flow injection analysis–electrospray ionization–Fourier transform ion cyclotron resonance mass spectrometry (FIA‐ESI‐FTICR‐MS) in negative and positive mode.ResultsQuantitative phytochemical profiling of the methanolic extract by UV–Vis spectroscopy indicated high contents of phenolic compounds (34.35 ± 3.59 mg EQ/g plant) and sugars (23.91 ± 1.99 mg EQ/g plant), while the qualitative profiling by FIA‐ESI‐FTICR‐MS allowed the tentative identification of several flavonoids and phenolic acids. Kaempferol‐3‐rutinoside, pelargonidin‐3‐(6″‐malonylglucoside)‐5‐glucoside, rutin, kaempferol‐3‐(2″,3″‐diacetyl‐4″‐p‐coumaroylrhamnoside), and myricetin‐3‐(2‴‐galloylrhamnoside) were the main compounds detected.ConclusionThe results expand our knowledge of the phytochemical constituents of petals from black D. pinnata.

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Comparative analysis of the main medicinal substances and applications of Echium vulgare L. and Echium plantagineum L.: A review

Cited by 14 publications

References 80 publications

Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson’s Curse (Echium plantagineum)

Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson’s Curse (Echium plantagineum)

The complete plastome of Echium plantagineum L. (Boraginaceae), the first chloroplast genome belonging to the Echium genus

Phytochemical profile of petals from black Dahlia pinnata by flow injection analysis–electrospray ionization–Fourier transform ion cyclotron resonance mass spectrometry

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