Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass

Liangos, Orfeas; Tighiouart, Hocine; Perianayagam, Mary C.; Kolyada, Alexey; Han, Won Kon; Wald, Ron; Bonventre, Joseph V.; Jaber, Bertrand L.

doi:10.1080/13547500903067744

Cited by 221 publications

(185 citation statements)

References 38 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…The AUCs for KIM-1 to predict AKI at the time of ICU admission ranged between 0.57 and 0.78. [48][49][50] The predictive value of KIM-1 increased and reached an AUC of 0.83 at 12 hours postoperatively, a time point at which organ injury might be advanced and irreversible. 50 KIM-1 in CIN.…”

Section: Cysc In Acs and Congestive Hfmentioning

confidence: 99%

“…In 3 studies 48,51,52 enrolling 258 patients undergoing cardiac surgery, urinary IL-18 showed a moderate predictive performance for AKI with an AUC ranging from 0.53 to 0.66 at postoperative ICU admission. Parikh and associates 51 concluded that the combination of urinary IL-18 with urinary NGAL may allow for the reliable early diagnosis and prognosis of AKI after CPB, much earlier than the rise in sCr.…”

Section: Il-18mentioning

confidence: 99%

See 1 more Smart Citation

Early Biomarkers of Renal Injury

Cruz

Goh

Haase-Fielitz

et al. 2010

Congestive Heart Failure

View full text Add to dashboard Cite

Congest Heart Fail. 2010;16(4)(suppl 1):S25–S31. ©2010 Wiley Periodicals, Inc.Cardiorenal syndrome (CRS) refers to pathophysiologic interaction of the heart and kidney and is associated with acute kidney injury (AKI) and high mortality. Cardiac surgery or acute decompensated heart failure and radiocontrast‐induced nephropathy are common clinical scenarios of CRS. Unfortunately, established functional biomarkers of glomerular filtration rate such as serum creatinine, urea, and diuresis delay AKI diagnosis by 24 to 48 hours. Novel renal biomarkers indicating tubular injury are emerging and may have wide implications. This review focuses on several novel renal biomarkers with the most promising biologic characteristics and clinical evidence for their AKI predictive ability: neutrophil gelatinase‐associated lipocalin, kidney injury molecule‐1, interleukin 18, and fatty acid–binding proteins. The value of each biomarker is reviewed on currently available clinical data in typical settings of CRS. These markers might extend the therapeutic window during which timely and individualized patient management might be possible.

show abstract

Section: Cysc In Acs and Congestive Hfmentioning

confidence: 99%

Section: Il-18mentioning

confidence: 99%

Early Biomarkers of Renal Injury

Cruz

Goh

Haase-Fielitz

et al. 2010

Congestive Heart Failure

View full text Add to dashboard Cite

show abstract

“…Cardiac surgery has long been used to study AKI because of the ability to prospectively follow patients before and after a well timed renal insult; for this reason, several urinary proteins have been shown to serve as biomarkers of AKI after cardiac surgery, including neutrophil gelatinase-associated lipocalin (NGAL) (16)(17)(18)(19)(20), cystatin C (CyC) (19,21), kidney injury molecule-1 (KIM-1) (18,21), interleukin-18 (IL-18) (22), and ␣-glutathione-S-transferase (␣-GST) (23,24). Limited data are available comparing the ability of these markers to predict renal outcomes at the time of AKI diagnosis.…”

mentioning

confidence: 99%

Urinary Biomarkers in the Clinical Prognosis and Early Detection of Acute Kidney Injury

Koyner¹,

Vaidya

Bennett

et al. 2010

Clinical Journal of the American Society of Nephrology

Self Cite

322

254

View full text Add to dashboard Cite

Background and objectives: Several novel urinary biomarkers have shown promise in the early detection and diagnostic evaluation of acute kidney injury (AKI). Clinicians have limited tools to determine which patients will progress to more severe forms of AKI at the time of serum creatinine increase. The diagnostic and prognostic utility of novel and traditional AKI biomarkers was evaluated during a prospective study of 123 adults undergoing cardiac surgery.Design, setting, participants, & measurements: Urinary neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), kidney injury molecule-1 (KIM-1), hepatocyte growth factor (HGF), -glutathione-S-transferase (-GST), ␣-GST, and fractional excretions of sodium and urea were all measured at preoperative baseline, postoperatively, and at the time of the initial clinical diagnosis of AKI. Receiver operator characteristic curves were generated and the areas under the curve (AUCs) were compared.Results: Forty-six (37.4%) subjects developed AKI Network stage 1 AKI; 9 (7.3%) of whom progressed to stage 3. Preoperative KIM-1 and ␣-GST were able to predict the future development of stage 1 and stage 3 AKI. Urine CyC at intensive care unit (ICU) arrival best detected early stage 1 AKI (AUC ‫؍‬ 0.70, P < 0.001); the 6-hour ICU NGAL (AUC ‫؍‬ 0.88; P < 0.001) best detected early stage 3 AKI. -GST best predicted the progression to stage 3 AKI at the time of creatinine increase (AUC ‫؍‬ 0.86; P ‫؍‬ 0.002).Conclusion: Urinary biomarkers may improve the ability to detect early AKI and determine the clinical prognosis of AKI at the time of diagnosis.

show abstract

“…Two other studies have found much greater sensitivity, of more than 90%, when KIM-1 is measured 2 and 6 h after cardiopulmonary bypass. However, it's sensitivity is decreased to 74% after 12 h cardiopulmonary bypass (34,35). Larger studies are needed to determine when is the optimal timing for determination and measurement of KIM-1 levels in relation to the exposure to etiological factors that may cause AKI.…”

Section: Discussionmentioning

confidence: 99%

Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates

et al. 2015

View full text Add to dashboard Cite

Background:The new urinary and serum biomarkers are discovered and are being investigated. With them we can diagnose acute kidney injury (AKI) faster and more precisely and they also have a significant role in the outcome prediction. Methods: The study included 22 extremely low-birthweight neonates who were hospitalized in the neonatal intensive care units. They were divided into two groups based on serum creatinine (SCr) level-with and without AKI. Detection and quantification of urinary kidney injury molecule-1 (uKIM-1) was done on the third day of life, using commercially available KIM-1 rapid test. Subsequently, measurements were repeated only in subjects who were diagnosed with AKI, at different values of SCr. results: Logistic regression analysis showed that AKI is an independent risk factor for mortality. In a group of neonates with AKI, 50% of neonates administered the KIM-1 rapid test showed positive findings. KIM-1 rapid test was positive in patients with a wide range of SCr levels (range of 78.73-385 µmol/l), but all subjects had oliguria and died in the next 24 h. conclusion: KIM-1 is a significant predictor of death. On the other hand, our study failed to prove that KIM-1 rapid test has any significance for early prediction of AKI.

show abstract

Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass

Cited by 221 publications

References 38 publications

Early Biomarkers of Renal Injury

Early Biomarkers of Renal Injury

Urinary Biomarkers in the Clinical Prognosis and Early Detection of Acute Kidney Injury

Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates

Contact Info

Product

Resources

About