Comparative analysis of whole blood transcriptomics between European and local Caribbean pigs in response to feed restriction in a tropical climate

Poullet, Nausicaa; Devarieux, Orianne; Beramice, David; Dantec, Laurent; Felicite, Yoann; Feuillet, Dalila; Gourdine, Jean-Luc; Bambou, Jean-Christophe

doi:10.1186/s12864-023-09381-7

Cited by 2 publications

(1 citation statement)

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“…These results seem to indicate that each HSP as a tissue-dependent expression in accordance with previous findings [ 43 – 47 ]. As in the literature, different patterns of gene expression were found between HSP70 and HSP90 families in HS conditions, dependent of the tissue and/or the duration and level of HS [ 45 , 48 , 49 ], possibly being a proxy of a tissue-specific susceptibility to HS. In other words, we cannot totally exclude that tissue variations in the HSP expression on d4 and d5 could also reflect differences in their expression kinetics in the first days of exposure to 32 °C.…”

Section: Discussionmentioning

confidence: 91%

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

Huau,

Liaubet,

Gourdine

et al. 2024

BMC Genomics

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Background Heat stress (HS) is an increasing threat for pig production with a wide range of impacts. When submitted to high temperatures, pigs will use a variety of strategies to alleviate the effect of HS. While systemic adaptations are well known, tissue-specific changes remain poorly understood. In this study, thirty-two pigs were submitted to a 5-day HS at 32 °C. Results Transcriptomic and metabolomic analyses were performed on several tissues. The results revealed differentially expressed genes and metabolites in different tissues. Specifically, 481, 1774, 71, 1572, 17, 164, and 169 genes were differentially expressed in muscle, adipose tissue, liver, blood, thyroid, pituitary, and adrenal glands, respectively. Regulatory glands (pituitary, thyroid, and adrenal) had a lower number of regulated genes, perhaps indicating an earlier sensitivity to HS. In addition, 7, 8, 2, and 8 metabolites were differentially produced in muscle, liver, plasma, and urine, respectively. The study also focused on the oxidative stress pathway in muscle and liver by performing a correlation analysis between genes and metabolites. Conclusions This study has identified various adaptation mechanisms in swine that enable them to cope with heat stress (HS). These mechanisms include a global decrease in energetic metabolism, as well as changes in metabolic precursors that are linked with protein and lipid catabolism and anabolism. Notably, the adaptation mechanisms differ significantly between regulatory (pituitary, thyroid and adrenal glands) and effector tissues (muscle, adipose tissue, liver and blood). Our findings provide new insights into the comprehension of HS adaptation mechanisms in swine.

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Section: Discussionmentioning

confidence: 91%

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

Huau,

Liaubet,

Gourdine

et al. 2024

BMC Genomics

Self Cite

View full text Add to dashboard Cite

show abstract

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

Huau,

Liaubet,

Gourdine

et al. 2023

Preprint

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View full text Add to dashboard Cite

Background Heat stress (HS) is an increasing threat for pig production with a wide range of impacts. When submitted to high temperatures, pigs will use a variety of strategies to alleviate the effect of HS. While systemic adaptations are well known, tissue-specific changes remain poorly understood. In this study, thirty-two pigs were submitted to a 5-day HS at 32° C.Results Transcriptomic and metabolomic analyses were performed on several tissues. The results revealed differentially expressed genes and metabolites in different tissues. Specifically, 481, 1774, 71, 1572, 17, 164, and 169 genes were differentially expressed in muscle, adipose tissue, liver, blood, thyroid, pituitary, and adrenal glands, respectively. Regulatory glands (pituitary, thyroid, and adrenal) had a lower number of regulated genes, perhaps indicating an earlier sensitivity to HS. In addition, 7, 8, 2, and 8 metabolites were differentially produced in muscle, liver, plasma, and urine, respectively. The study also focused on the oxidative stress pathway in muscle and liver by performing a correlation analysis between genes and metabolites.Conclusions This study has identified various adaptation mechanisms in swine that enable them to cope with heat stress (HS). These mechanisms include a global decrease in energetic metabolism, as well as changes in metabolic precursors that are linked with protein and lipid catabolism and anabolism. Notably, the adaptation mechanisms differ significantly between regulatory (pituitary, thyroid and adrenal glands) and effector tissues (muscle, adipose tissue, liver and blood). Our findings provide new insights into the comprehension of HS adaptation mechanisms in swine.

show abstract

Comparative analysis of whole blood transcriptomics between European and local Caribbean pigs in response to feed restriction in a tropical climate

Cited by 2 publications

References 65 publications

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine

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