"Comparative Analytic Study by UV Spectrophotometric, Structural Characterization through Fourier Transformed Infrared Spectroscopy (FTIR) Method and Disintegration Analysis for Different Brands of Amlodipine Tablets Available in Malaysia"

Abstract

Background: To evaluate the percentage purity of different brands of amlodipine tablets available in local market by using UV-Spectrophotometric method and structural characterization through FTIR Spectroscopy.Objective(s): Quantitative determination of different brands of amlodipine tablets available in Malaysia by using UV spectrophotometric and Fourier transform infrared red spectroscopy method. To provide simple and cost-effective spectrophotometric method for quantitative analysis.Material And Methods: For UV-spectrophotometric method, the amlodipine sample was treated with methanol as a solvent. For structural characterization method, amlodipine powdered sample was placed onto the crystal plate and scanned by using spectrum software. Disintegration tester was used for amlodipine tablets. The temperature of the distilled water was maintained at 37˚C (±1˚C).Results and Discussion: For UV-Spectrophotometric method, the samples D and E had passed the limit specified by British Pharmacopoeia (B.P), whereas sample D, E, F, G and H had passed the limit specified by United State Pharmacopeia (U.S.P). For structural characterization, the functional groups of alkynes, alkanes, alkenes and organic halides were present in all the amlodipine samples with the respective wavelength number. A total of eight brands of amlodipine tablets were used in the research. All the different brands of amlodipine tablets were disintegrated within15 minutes. This indicated that the amlodipine tablets can be rapidly absorbed through oral route. Conclusion:The brand D was the best pure, while brand A showed poor purity of drug among all other eight brands of Amlodipine tablets. The assay of the pharmaceutical products should be always performed to ensure the product was maintained in safety, quality, quantity and efficacy condition. All the brands of amlodipine tablets with a temperature of 37˚C (±1˚C) disintegrated within 15 minutes and results showed that the orally taken drug can be easily disintegrated into human body.