Comparative and serial assays of folate metabolism in anticonvulsant-treated epileptics

Homocysteine concentrations and methionine loading in patients on antipileptic drugs

“…An inverse relationship between p-tHcy concentrations and serum folate (S-FA) levels has previously been reported (8). Patients on AEDs often have somewhat lower levels of S-FA and erythrocyte folate (E-FA) than controls (9,10). This is probably in accordance with the high prevalence of macrocytotic erythrocytes without anemia in these patients (11).…”