Comparative and synergistic activity of<i>Rosmarinus officinalis</i>L. essential oil constituents against the larvae and an ovarian cell line of the cabbage looper,<i>Trichoplusia ni</i>(Lepidoptera: Noctuidae)

Tak, Jun‐Hyung; Jovel, Eduardo; Isman, Murray B.

doi:10.1002/ps.4010

Cited by 143 publications

(97 citation statements)

References 35 publications

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“…The colony was maintained on a pinto bean-based artificial diet (Bio-Serv Inc., Frenchtown, NJ, USA) at 23–26°C and a 16:8 h LD photoperiod. Insecticidal activities of 82879 and the positive control permethrin were evaluated via topical application [65]. In brief, each of ten third instar larvae received 1 μL of DMSO solution of the test compounds or DMSO alone as the negative control using a Hamilton Microliter syringe attached to a repeating dispenser.…”

Section: Methodsmentioning

confidence: 99%

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

et al. 2016

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The apolipoprotein E (APOE) gene is the most highly associated susceptibility locus for late onset Alzheimer’s Disease (AD), and augmenting the beneficial physiological functions of apoE is a proposed therapeutic strategy. In a high throughput phenotypic screen for small molecules that enhance apoE secretion from human CCF-STTG1 astrocytoma cells, we show the chrysanthemic ester 82879 robustly increases expressed apoE up to 9.4-fold and secreted apoE up to 6-fold and is associated with increased total cholesterol in conditioned media. Compound 82879 is unique as structural analogues, including pyrethroid esters, show no effect on apoE expression or secretion. 82879 also stimulates liver x receptor (LXR) target genes including ATP binding cassette A1 (ABCA1), LXRα and inducible degrader of low density lipoprotein receptor (IDOL) at both mRNA and protein levels. In particular, the lipid transporter ABCA1 was increased by up to 10.6-fold upon 82879 treatment. The findings from CCF-STTG1 cells were confirmed in primary human astrocytes from three donors, where increased apoE and ABCA1 was observed along with elevated secretion of high-density lipoprotein (HDL)-like apoE particles. Nuclear receptor transactivation assays revealed modest direct LXR agonism by compound 82879, yet 10 μM of 82879 significantly upregulated apoE mRNA in mouse embryonic fibroblasts (MEFs) depleted of both LXRα and LXRβ, demonstrating that 82879 can also induce apoE expression independent of LXR transactivation. By contrast, deletion of LXRs in MEFs completely blocked mRNA changes in ABCA1 even at 10 μM of 82879, indicating the ability of 82879 to stimulate ABCA1 expression is entirely dependent on LXR transactivation. Taken together, compound 82879 is a novel chrysanthemic ester capable of modulating apoE secretion as well as apoE-associated lipid metabolic pathways in astrocytes, which is structurally and mechanistically distinct from known LXR agonists.

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Section: Methodsmentioning

confidence: 99%

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

et al. 2016

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“…[31] The inhibition of mycelial growth of B. mediterannea by essential oils may prove the presence of toxic compounds, which are active against fungi. [33] Indeed, their ability to destroy fungal membrane is due to their lipophilic properties and also to specific functional groups of their compounds.…”

Section: Antifungal Activity Of Eucalyptus Essential Oils Againstmentioning

confidence: 99%

Essential Oils of Myrtaceae Species Growing Wild in Tunisia: Chemical Variability and Antifungal Activity Against Biscogniauxia mediterranea, the Causative Agent of Charcoal Canker

Yangui

Boutiti

Boussaïd

et al. 2017

Chemistry & Biodiversity

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The chemical composition of five Eucalyptus species and five Myrtus communis L. populations was investigated using GC/MS and GC-FID. For Eucalyptus essential oils, 32 compounds, representing 88.56 - 96.83% of the total oil according to species, were identified. The main compounds were 1,8-cineole, α-pinene, p-cymene, γ-gurjunene, α-aromadendrene, and β-phellandrene. For Myrtle essential oils, 26 compounds, representing 93.13 - 98.91% of the total oil were identified. α-Pinene, 1,8-cineole, linalool, and myrtenyl acetate were found to be the major compounds. Principal component analysis (PCA) showed chemical differentiation between Eucalyptus species and between Myrtle populations. Biscogniauxia mediterranea, the causative agent of charcoal canker, was identified according to its morphological and molecular characteristics. Essential oils of the investigated Eucalyptus species and Myrtle populations were tested for their antifungal capacity against this fungus. The antifungal activity varied according to the essential oil composition. Biscogniauxia mediterranea exhibited powerful resistance to some essential oils including them of Eucalyptus lehmannii and Eucalyptus sideroxylon but it was very sensitive to Eucalyptus camaldulensis oil (IC = 3.83 mg/ml) and M. communis oil from Zaghouan (IC = 1 mg/ml). This sensitivity was found to be correlated to some essential oil compounds such as p-cymene, carvacrol, cuminaldehyde, and linalool.

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“…In addition, they may interfere with growth, reproduction of the insects, or act on their olfactory receptors, inducing attraction or repellency effects (Sukumar, Perich & Boombar, 1991; Isman, 2000; Gonzalez-Coloma et al, 2011). Essential oils and their pure components possess an extraordinary bioactivity, being reported their use against a wide range of insect pest, e.g., Aedes aegypti (Lucia et al, 2007; Lucia et al, 2008; Lucia et al, 2009; Lucia et al, 2012; Pavela, 2015), Pediculus humanus capitis (Toloza et al, 2008; Toloza, Vassena & Picollo, 2008), Tribolium castaneum and Sitophilus oryzae (Lee, Peterson & Coats, 2003; Lopez, Contreras & Villalobos, 2008; Stefanazzi, Stadler & Ferrero, 2011) Trichoplusia ni (Tak, Jovel & Isman, 2015; Tak & Isman, 2015). Essential oils have even been evaluated against different insect pest from more than 100 years; their practical use is rather limited.…”

Section: Introductionmentioning

confidence: 99%

Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control

Lucı́a

Toloza

Guzmán

et al. 2017

PeerJ

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BackgroundEssential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability and manageability due to their dispersion in water can open new perspective for the preparation of formulations for the control of insect pest. In this work, we studied the encapsulation of different monoterpenes in a poloxamer shell in order to prepare aqueous formulations that can be used for the development of platforms used in pest control.MethodsMicellar systems containing a 5 wt% of poloxamer 407 and 1.25 wt% of the different monoterpenes were prepared. Dynamic Light Scattering (DLS) experiments were carried out to characterize the dispersion of the EOCs in water. The pediculicidal activity of these micellar systems was tested on head lice using an ex vivo immersion test.ResultsThe poloxamers allowed the dispersion of EOCs in water due to their encapsulation inside the hydrophobic core of the copolymer micelles. From this study, we concluded that it is possible to make stable micellar systems containing water (>90 wt%), 1.25 wt% of different monoterpenes and a highly safe polymer (5wt% Poloxamer 407). These formulations were effective against head lice with mortality ranging from 30 to 60%, being the most effective emulsions those containing linalool, 1,8-cineole, α-terpineol, thymol, eugenol, geraniol and nonyl alcohol which lead to mortalities above 50%.DiscussionSince these systems showed good pediculicidal activity and high physicochemical stability, they could be a new route for the green fabrication of biocompatible and biosustainable insecticide formulations.

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Comparative and synergistic activity ofRosmarinus officinalisL. essential oil constituents against the larvae and an ovarian cell line of the cabbage looper,Trichoplusia ni(Lepidoptera: Noctuidae)

Abstract: Based on our results, the insecticidal activity of rosemary oil appears to be a consequence of the synergistic interaction between 1,8-cineole and (±)-camphor, and (±)-camphor should be considered a promising synergizing agent.

Cited by 143 publications

References 35 publications

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

Essential Oils of Myrtaceae Species Growing Wild in Tunisia: Chemical Variability and Antifungal Activity Against Biscogniauxia mediterranea, the Causative Agent of Charcoal Canker

Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control

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