Comparative antimicrobial activity of fractions of &lt;i&gt;Vernonia glaberrima&lt;/i&gt; against selected human pathogens

Abdullahi, M. I.; Uba, A.; Yusuf, A. J.; Olowo-Okere, Ahmed; Nasir, Idris Abdullahi; Muntaka, Abdulrahman; Alhassan, Alhassan Muhammad; Bello, Sani Sa’idu; Alebiosu, Celestina O.; Umar, Abdulrashid; Yahaya, Maryam; Abubakar, H.

doi:10.4314/jpb.v14i2.10

Cited by 4 publications

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“…A total of 14 studies about the in vitro antibacterial activity of medicinal plants from Sub-Saharan Africa against Campylobacter spp. were found [23][24][25][26][27][28][29][30][31][32][33][34][35][36]. e majority of studies were from Nigeria (5 studies), South Africa (4), and Guinea-Bissau (3).…”

Section: Database Search Resultsmentioning

confidence: 99%

“…Nine studies tested the antimicrobial activity for Campylobacter spp. through the MIC [23,24,26,[29][30][31][33][34][35], while five studies tested only through disk diffusion method [25,27,28,32,36]. Table 1 provides a summary of the studied plant extracts, plant parts, isolated compounds, diameter of inhibition, MIC, and MBC of the tested plants.…”

Section: Results Of the In Vitromentioning

confidence: 99%

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A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Hlashwayo

Barbosa

Langa

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. Campylobacter spp. are zoonotic bacteria that cause gastroenteritis in humans and may cause extraintestinal infections such as Guillain-Barré syndrome, reactive arthritis, and bacteremia. Resistance to antibiotics is an increasing concern in the Sub-Saharan Africa; thus, search for alternatives such as plant-based active ingredients is important in order to develop new drugs. Objectives. To present a systematic review of in vitro and in vivo studies of the antibacterial activity of medicinal plants from Sub-Saharan Africa against Campylobacter spp. Methodology. Studies published until March 2020 on medicinal plants used against Campylobacter spp. from each country of Sub-Saharan Africa were searched on PubMed, Science Direct, AJOL, and Google Scholar. Articles were selected based on the existence of information regarding in vitro and in vivo activity of medicinal plants against Campylobacter spp. Results. A total of 47 medicinal plants belonging to 28 families were studied for in vitro activity against Campylobacter spp. No plant was studied in vivo. Plants from Fabaceae family were the most commonly studied. The plants with the strongest antimicrobial activities were Cryptolepis sanguinolenta and Terminalia macroptera. The root extracts from these plants were effective, and both had a minimal inhibitory concentration (MIC) of 25 μg/ml. Seven pure compounds were isolated and analyzed for activity against Campylobacter spp. The compound cryptolepine from C. sanguinolenta was the most effective with MIC values ranging between 6.25 and 25 μg/ml. Conclusion. Several native plants from the Sub-Saharan Africa region were studied for in vitro activity against Campylobacter spp. Some plants seemed very effective against the bacteria. Chemical compounds from three plants have been isolated and analyzed, but further studies are needed in order to produce new and effective drugs.

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Section: Database Search Resultsmentioning

confidence: 99%

Section: Results Of the In Vitromentioning

confidence: 99%

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Hlashwayo

Barbosa

Langa

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Methanolic and dichloromethane extracts have been found to show positive micronucleus tests, suggesting their clastogenic and or aneuploidic activity [102]. However, an independent study found that the intraperitoneal LD 50 of the crude methanolic V. glaberrima extract was 1265 mg/kg, indicating its fairly toxic nature [103]. V. amygdalina leaf extract exhibited no observable clinical signs of toxicity or adverse toxicological properties [104,105].…”

Section: Toxicological Studiesmentioning

confidence: 99%

Antidiabetic Potential of Phytochemicals Found in Vernonia amygdalina

Talwar,

Chakraborty,

Zahera

et al. 2024

Journal of Chemistry

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Type 2 diabetes mellitus (T2DM), or “insulin-independent diabetes mellitus,” is a worldwide health concern. Diabetes affects roughly 415 million individuals worldwide, with 193 million undiagnosed cases. The number of people afflicted in the following decades is predicted to double. Although various synthetic medications are currently available to treat/manage T2DM, their side effects compel researchers to seek novel treatment options. Because of their affinity for biological receptors and broad bioactivity, nature has long been a source of innovative medication. V. amygdalina is one of the numerous natural productswith antidiabetic properties. Several studies have shown that the extracts have antidiabetic effects in vitro and in vivo. This review examined the antidiabetic and pharmacokinetic characteristics of phytoconstituents found in V. amygdalina.

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“…Chemical investigations on the leaf of the plant have been confined to the isolation and characterisation of fatty acids, steroids and coumarins (Emily & Gari 2008). Pharmacological studies ranging from anticancer, analgesic, anti-inflammatory, antimalarial, anti-diabetic, antimicrobial and antiviral activities have also been reported (Abdullahi et al 2015b(Abdullahi et al , 2015c(Abdullahi et al , 2015d(Abdullahi et al , 2017Alhassan et al 2018;Ananil et al 2000). This study was conducted to evaluate the analgesic and anti-inflammatory activities of lupeol from V. glaberrima leaf.…”

Section: Introductionmentioning

confidence: 99%

Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation

Yusuf

Abdullahi

Umar

et al. 2020

Journal of Medicinal Plants for Economic Development

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Background: Steroids have been reported to possess analgesic and anti-inflammatory activities, and Vernonia glaberrima also possesses analgesic and anti-inflammatory properties. Aim:The aim of the study was to evaluate the effect of lupeol isolated from the n-hexane soluble fraction of the methanol leaf extract of V. glaberrima on pain and inflammation.Method: Lupeol was re-isolated from the leaf of V. glaberrima by using chromatographic procedures; it was subjected to analgesic and anti-inflammatory studies by using acetic acidinduced writhing test in mice and formalin-induced pain and inflammation in rats, respectively. The intraperitoneal lethal dose (LD 50 ) of lupeol was determined by using Lorke's method. Results:The results of the study showed that lupeol significantly (p < 0.05) decreased writhing response at doses 12.5 mg/kg, 25.0 mg/kg and 50.0 mg/kg corresponding to percentage inhibition of 83.60%, 83.63% and 80.02%, respectively. This was higher than piroxicam, the standard drug (73.8%), at 10 mg/kg. The compound was also able to significantly (p < 0.05) reduce nociceptive response in both phases of the formalin test, and there was a remarkable reduction of oedema by the compound at the second, third and fourth hours. The median LD 50 of the compound was estimated to be greater than 5000 mg/kg. Conclusion:The findings of this study indicated that lupeol from the leaf of V. glaberrima has good analgesic and anti-inflammatory activity that validates the ethnomedicinal use of the plant in the treatment of pain and inflammatory conditions.

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Comparative antimicrobial activity of fractions of <i>Vernonia glaberrima</i> against selected human pathogens

Cited by 4 publications

References 0 publications

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Antidiabetic Potential of Phytochemicals Found in Vernonia amygdalina

Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation

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