Comparative antimicrobial activity of the new macrolides againstBorrelia burgdorferi

Preac-Mursic, V.; Wilske, Bettina; Schierz, G; Süß, E.; Gross, Birgit

doi:10.1007/bf01968150

Cited by 63 publications

(41 citation statements)

References 7 publications

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“…Studies of the effects of antibiotic therapy in animals infected with B. burgdorferi have been conducted most often with mice (8,18,25,30,31,35,38,53,54) but also with hamsters (21,22), gerbils (15,32,42), dogs (48,49), and nonhuman primates (39). In most of the studies the animals were immunocompetent, but in several the animals were immunocompromised (25,37,48).…”

Section: Animal Studies: General Remarksmentioning

confidence: 99%

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Wormser

Schwartz

2009

Clin Microbiol Rev

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SUMMARY Despite resolution of the objective manifestations of Lyme disease after antibiotic treatment, a minority of patients have fatigue, musculoskeletal pain, and/or difficulties with concentration or short-term memory of uncertain etiology; these are called post-Lyme disease symptoms or, in more severe cases, post-Lyme disease syndrome or “chronic Lyme disease.” Several recent studies in which Borrelia burgdorferi-infected animals were treated with antibiotic therapy have demonstrated the presence of PCR positivity for B. burgdorferi DNA in the absence of culture positivity. In mice that were treated with antibiotic therapy, residual spirochetes could be taken up by ticks during a blood meal and could be transmitted to SCID mice. These spirochetes are attenuated; their presence is not associated with either inflammation or disease. In this review the methodology and findings of these studies are critically analyzed, and the significance of the results with regard to human Lyme disease is evaluated, with special emphasis on whether these studies provide useful insights into post-Lyme disease syndrome. A serious methodological concern is the failure to consider the pharmacokinetic-pharmacodynamic properties of the antibiotic in choosing the dosage regimen used. We conclude that there is no scientific evidence to support the hypothesis that such spirochetes, should they exist in humans, are the cause of post-Lyme disease syndrome.

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Section: Animal Studies: General Remarksmentioning

confidence: 99%

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Wormser

Schwartz

2009

Clin Microbiol Rev

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“…[1][2][3][4] Meningitis, cranial neuritis and painful radiculoneuritis have been reported to be common neurological disorders in this infection. '-* Diagnosis of borreliosis of the central nervous system relies mainly on clinical and serological features.…”

Section: Introductionmentioning

confidence: 99%

Detection of Borrelia burgdorferi in cerebrospinal fluid by the polymerase chain reaction

Krüger

Pulz

1991

Journal of Medical Microbiology

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“…In vitro, B. burgdorferi is susceptible to a number of agents, including macrolides, tetracyclines, and 1-lactam antibiotics (11,13,(16)(17)(18)20 (12,14).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo

Alder

Mitten

Jarvis

et al. 1993

Antimicrob Agents Chemother

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Clarithromycin provided effective therapy against arthritis induced by Borrelia burgdorferi infection in the hamster. In vitro, clarithromycin was at least 1 log more potent than tetracycline against two isolates of B.burgdorfieri from human sources, as measured by MICs and 50%Y inhibitory concentrations. Clarithromycin was effective in preventing the onset of B. burgdoferi-induced arthritis, as determined by several parameters of paw swelling. When administered after the onset of arthritis, clarithromycin therapy reduced the degree of swelling and decreased recovery time. These results suggest that clarithromycin has potential as an effective therapy for Lyme disease.

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Comparative antimicrobial activity of the new macrolides againstBorrelia burgdorferi

Cited by 63 publications

References 7 publications

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Detection of Borrelia burgdorferi in cerebrospinal fluid by the polymerase chain reaction

Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo

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