Comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection

Dubey, Sandeep; Saha, Suparna; Rajkumar, Balakrishnan; Dhole, Tapan Kumar

doi:10.4103/ejd.ejd_141_16

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…sodium hypochlorite) do not completely sterilize the root canal system 36 . The concept of irrigation with MTAD (antibiotic solution) might be improved in combination with UV irradiation 37 . In addition, postoperative infections adjacent to biomedical dental implants remain a significant problem, which can lead to early implant failure 38 .…”

Section: Discussionmentioning

confidence: 99%

UV light assisted antibiotics for eradication of in vitro biofilms

Argyraki

Markvart

Stavnsbjerg

et al. 2018

Sci Rep

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The overuse of antibiotics is accelerating the bacterial resistance, and therefore there is a need to reduce the amount of antibiotics used for treatment. Here, we demonstrate in vitro that specific wavelengths in a narrow range around 296 nm are able to eradicate bacteria in the biofilm state (grown for 24 hours) more effectively, than antibiotics and the combination of irradiation and antibiotics is even better, introducing a novel concept light assisted antibiotics. The investigated wavelength range was 249 nm to 338 nm with an approximate step of 5 nm. The novel concept that consists of a UV irradiation treatment followed by a tobramycin treatment can significantly reduce the amount of antibiotics needed for eradicating mature bacterial biofilms. The efficiency of the proposed light assisted antibiotics method was compared to combinatory antibiotic treatment and highly concentrated antibiotic monotherapy. The eradication efficacies, on mature biofilms, achieved by light assisted antibiotic and by the antibiotic monotherapy at approximately 10-fold higher concentration, were equivalent. The present achievement could motivate the development of light assisted antibiotic treatments for treating infections.

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Section: Discussionmentioning

confidence: 99%

UV light assisted antibiotics for eradication of in vitro biofilms

Argyraki

Markvart

Stavnsbjerg

et al. 2018

Sci Rep

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“…2 The instrumentation is effective in disorganizing the bacterial biofilm and reducing the presence of microorganisms in the main root canal. [3][4][5] However, it is necessary for the aid of the irrigation through chemical substances to potentiate the cleaning and disinfection of the canal system. Enterococcus faecalis is one of the most common species found in persistent root canal infections.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Three Irrigation Systems in the Enterococcus faecalis Reduction after Instrumentation with a Reciprocating Instrument

et al. 2020

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Objective This study aimed to analyze the effectiveness of three irrigation systems: EndoActivator, passive ultrasonic irrigation (PUI), and Easy Clean in the reduction of Enterococcus faecalis, after instrumentation with the reciprocating system, through microbiological collection and culture method. Materials and Methods A total of 60 extracted human lower premolars were used and standardized at 16 mm in length. The teeth were accessed, contaminated with E. faecalis, and incubated for 21 days at 37°C. Initial collections (S1) were made with an absorbent paper cone to confirm the contamination; subsequently, instrumentation was performed with WaveOne Primary. The teeth were divided into four groups according to the final irrigation protocol (n = 15): group 1. EndoActivator; group 2, PUI; group 3, Easy Clean; and group 4, control group irrigated with saline solution sterile and without agitation. In the final irrigation, the agitation of the 17% ethylene amine tetra-acetic acid (EDTA) solutions was used, then 2.5% sodium hypochlorite (NaOCl); in both for this, three cycles of 20 seconds each. After the chemical–mechanical preparation and agitation of the irrigating solutions, the final collections (S2) for counting the colony-forming units (CFU/mL) occurred. Results The Kruskal–Wallis test revealed that all the agitation systems reduced by 100% and the control group by 65.7%. Conclusion The control group presented a significantly higher amount of CFU/mL after the chemical–mechanical preparation than the other groups, which were similar to each other (p > 0.05).

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“…21 Several antibiotics are considered safe in pregnancy and breastfeeding including amoxicillin, azithromycin, and clindamycin. Metronidazole is a broad-spectrum antibiotic that is effective against anaerobic bacteria and protozoa, 22 and although it is safe in pregnancy, its use in breastfeeding is not recommended because it may affect the taste of milk adversely. 21 Within the context of vulnerable populations, there were two types of infections affecting infants younger than 2 years: acute herpetic gingivostomatitis and pseudomembranous candidiasis.…”

Section: Discussionmentioning

confidence: 99%

Utilization of Teledentistry in Antimicrobial Prescribing and Diagnosis of Infectious Diseases during COVID-19 Lockdown

et al. 2020

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Objectives This study aimed to analyze Jordanian dentists’ inquiries on oral infections and antimicrobial prescribing using dental professional WhatsApp groups during coronavirus disease lockdown period. Materials and Methods Three professional WhatsApp groups of Jordanian dentists were reviewed and analyzed for inquiries posted during the period from January to May 2020. Inquiries were sent from patients to their dentists who posted these inquiries to the professional WhatsApp dental groups for consultation and professional advice. All queries regarding oral infections and antimicrobial prescribing were extracted and analyzed. Results Three WhatsApp professional groups with a total numbers of members of 750 dentists who posted queries about their patients were included in this study. Dentist members posted queries about their patients to these professional WhatsApp groups. There was a total of 32 inquiries regarding oral lesions and 11 consultations regarding prescribing and dental management of medically compromised patients giving a total of 43 consultations. Among which there were 19 inquiries on oral infections and 9 inquiries on antimicrobial prescribing giving a total of 28 consultations. Most common inquiries were on bacterial infections (localized dentoalveolar abscess, pericoronitis, cellulitis, and lymphoid hyperplasia of the tongue), viral herpetic infections, and Candida infections (erythematous and pseudomembranous candidiasis). Conclusions Many dental practitioners cannot distinguish the correct diagnostic features of oral infections particularly viral and fungal infections. Continuing education should be considered to focus on clinical manifestations of various oral infections. Further, educational activities that focus on variations in treatment protocols for various infections should be introduced particularly those that concern indications for antimicrobial prescribing.

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Comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection

Cited by 12 publications

References 21 publications

UV light assisted antibiotics for eradication of in vitro biofilms

UV light assisted antibiotics for eradication of in vitro biofilms

The Effectiveness of Three Irrigation Systems in the Enterococcus faecalis Reduction after Instrumentation with a Reciprocating Instrument

Utilization of Teledentistry in Antimicrobial Prescribing and Diagnosis of Infectious Diseases during COVID-19 Lockdown

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