Comparative Antioxidant Analysis of Moringa oleifera Leaf Extracts from South Western States in Nigeria

Abstract

Background Moringa oleifera is a medicinal plant that ethnobotanical studies have shown its inclusion in treatment of many ailments such as diarrhea, diabetes, epilepsy, wound healing and arthritis. It is a plant that was believed to originate from India but could now be found in both the tropics and the sub-topics. Earlier reports have not addressed the association between the location of plant collection and its antioxidant contents. In this study, Moringa oleifera leaves were collected from 21 locations within the south western states of Nigeria. Leaves from each of the locations were dried and evaluated for total phenols, tannin, saponin and flavonoid. DPPH scavenging activity, nitric oxide scavenging activity and inhibition of lipid peroxidation were also evaluated. Results All the parameters analysed showed significant within- and between-group differences. Some locations had greater DPPH scavenging ability than the standard (quercetin). Conclusion Environmental parameters like annual precipitation, minimum temperature and maximum temperature, and soil type of the location of the plants showed influence on the level of antioxidant, while further analysis using metaboanalyst showed a notable effect of soil type on the antioxidant activity.

Functional cereals' anti‐diabetic property, phenolic composition, and role on glycemic indices in‐vitro

“…Phenolic acid and flavonoid compounds are known as potent radical scavengers and metals chelators (Ademosun et al, 2016). Olaoye et al (2021) reported on the total phenols, tannin, saponin, and flavonoids of moringa leaf leaves in‐vitro and its antioxidant activity on DPPH scavenging activity, nitric oxide scavenging activity, and lipid peroxidation reaction. Fruit peels of lemon, orange, and pomegranate are good sources of antioxidant polyphenols (Arora & Kaur, 2013) and Kopsell et al (2009) gives report of phenolic content to be present in maize.…”

A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications

“…The antioxidant properties of Moringa were also greatly influenced by environmental parameters such as annual precipitation, minimum temperature, and maximum temperature on soil. Therefore, a recent study was conducted to determine the antioxidant properties of phenolic content in NP M. oleifera [ 103 ]. Therefore, studying the antioxidant capabilities of M. oleifera NPs produced using distinct extracts derived from different places is vital.…”

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“…Since Metformin, a standard anti-diabetic drug employed in this study could not to protect against neuronal damage sufficiently similar to a precious report (Ekong et al 2022), it could be adduced that M. oleifera and V. amygdalina confer tissue protection by mechanism other than normalizing blood sugar. M. oleifera and V. amygdalina are rich sources of phenols, vitamins C and E which are well known antioxidants (Ganguly et al 2005;Olaoye et al 2021). This neuroprotective effect may be attributed to these antioxidants (Ekong et al 2017;Oladele et al 2020;Alara and Abdurahman 2021).…”

“…Moringa oleifera is used in folk medicine to treat diabetes (Dieye et al 2008;Nku-Ekpang et al 2015;Frederick et al 2020), as well as in the treatment of rheumatism, venom and microbial infections (Rajnish et al 2012). It is a rich source of antioxidant phytochemicals such as phenolic acids and flavonoids which play important roles in the defence against free radicals (Xu et al 2019;Olaoye et al 2021). It is believed that the antidiabetic properties of M. oleifera may be due its terpenoid constituents.…”