Comparative antioxidant scavenging and lipid peroxidation activity of rutin and gallic acid

Khan, Rahmat Ali; Khan, Muhammad Rashid; Khan, Arif

doi:10.3329/bjp.v10i3.23362

Cited by 8 publications

(3 citation statements)

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“…Similar protective effects comments were also reported by using Alnus nitida against CCl 4 induced oxidative stress in liver [34]. Presence of various polyphenols in the extract might be responsible for the scavenging of free radicals and in the inhibition of lipid peroxidation [35]. Different studies have also reported protective effects of various plant extracts against the CCl 4 induced hepatic damages in rat [17, 18, 31].…”

Section: Discussionsupporting

confidence: 58%

Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats

Batool

Khan

Majid

2017

BMC Complement Altern Med

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BackgroundEvaluation of Euphorbia dracunculoides of family Euphorbiaceae during previous studies had established the in vitro antioxidant and in vivo anti-inflammatory activities. The plant is used by the local communities of Pakistan for various disorders including rheumatism and edema. In this investigation we have evaluated the hepatoprotective effects against CCl4 induced toxicity in rat.MethodsDry powder of the aerial parts of E. dracunculoides was extracted with 95% methanol to get the extract (EDME). To investigate the hepatoprotective effects of EDME the Sprague-Dawley male rats were divided in to 8 groups with 6 rats in each. Group I and II were the normal and vehicle treated while the Groups III-VI were injected intraperitoneally with 1 ml of CCl4 (30% in olive oil). Rats of Group IV were orally administered with silymarin (50 mg/kg) while the Group V and VI with 200 mg/kg and 400 mg/kg of EDME, respectively. Animals of Group VII (200 mg/kg) and VIII (400 mg/kg) were treated with EDME alone. The treatments were given thrice a week for 4 weeks. Effects of EDME were evaluated for the protective effects against oxidative stress and genotoxicity induced with CCl4 in liver of rat.ResultsAnalysis of serum indicated significant (p < 0.05) rise in the level of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and globulin whereas decrease was recorded for the total protein and albumin in CCl4 treated rats. In liver tissues the activity level of catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), glutathione-S-transferase (GST), glutathione (GSH) was decreased while the level of lipid peroxides; thiobarbituric acid reactant substances (TBARS), nitrite and hydrogen peroxide increased in CCl4 treated rats as compared to the control group. Histopathological injuries and DNA damages were recorded in liver of rat with CCl4 treatment. However, co-administration of EDME, dose dependently, ameliorated the CCl4-induced hepatic toxicity in these parameters.ConclusionsThese results suggested that the phyto-constituents of EDME were able to ameliorate the oxidative stress induced with CCl4 and can be a useful therapeutic agent for oxidative stress related disorders.

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Section: Discussionsupporting

confidence: 58%

Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats

Batool

Khan

Majid

2017

BMC Complement Altern Med

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“…The geographical origin has been shown to affect the antioxidant capacity of REO which assumed a value in the range of 16.45 mg/mL to 23.8 mg/mL if was from China or the Mediterranean region. The GA IC 50 value determined in this work was slightly lower than the one reported by Khan and colleagues [34] who found that the IC 50 of gallic acid was equal to 19.0 µg/mL. The DPPH radical scavenging capacity of SC solution with GA (SC/GA) and REO (SC/REO) is shown in Figure 3.…”

Section: Antioxidant Activitycontrasting

confidence: 61%

Active Biopolymer Coating Based on Sodium Caseinate: Physical Characterization and Antioxidant Activity

Valentino¹,

Volpe

Giuseppe³

et al. 2020

Coatings

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The objective of this work was to investigate the effect of sodium caseinate concentration on physical-chemical properties of coating solutions and films obtained by casting as a starting point for the development of an active coating for minimally processed fruits or vegetables. Sodium caseinate solutions at different concentrations (4%, 8%, 10%, 12%, 14%) were used as a coating system. The coating viscosity and desorption kinetic were characterized. Minimally processed fennels were coated by dipping and the liquid and dry coating thickness were estimated by assessing the amount of coating on fennel during draining as a function of solution properties (concentration and viscosity). Film obtained by casting were also characterized in terms of equilibrium moisture content, color, and water vapor permeability. The potential of using the sodium caseinate solution to obtain active coating was investigated by adding gallic acid or rosemary oil to sodium caseinate solution at 4%. The antioxidant capacity of the coating was evaluated by DPPH test. Results show that sodium caseinate solutions follow a Newtonian behavior in the range of concentration investigated and the viscosity increased as solids concentration increased, following a power law. The drying rate was in the range 0.0063–0.00107 mgH2O·mgsolids−1·min−1·m−2 as a function of sodium caseinate concentration. The average liquid and dry coating thickness on fennels were in the range 20–70 and 0.7–6.4 μm, respectively. The water vapor permeability slightly decreased as the solid concentration increased. Active coating showed good antioxidant properties.

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“…According to data shown in Table 2 , AKP and AP fractions had higher antioxidant activities, with the AKP fraction being more effective in DPPH/FRAP/ORAC assays. Previous reports indicate that at least in the case of phenolic acids, combined antioxidant effects could be observed due to their molecular interactions [ 21 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of ‘Ataulfo’ Mango Peel on LS180 Cells

et al. 2018

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Mango “Ataulfo” peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP’s antioxidant activity. The content (HPLC-DAD), antioxidant (DPPH, FRAP, ORAC), and antiproliferative activities (MTT) of free (FP) and chemically-released PP from mango ‘Ataulfo’ peel after alkaline (AKP) and acid (AP) hydrolysis, were evaluated. AKP fraction was higher (µg/g DW) in gallic acid (GA; 23,816 ± 284) than AP (5610 ± 8) of FR (not detected) fractions. AKP fraction and GA showed the highest antioxidant activity (DPPH/FRAP/ORAC) and GA’s antioxidant activity follows a single electron transfer (SET) mechanism. AKP and GA also showed the best antiproliferative activity against human colon adenocarcinoma cells (LS180; IC50 (µg/mL) 138.2 ± 2.5 and 45.7 ± 5.2) and mouse connective cells (L929; 93.5 ± 7.7 and 65.3 ± 1.2); Cheminformatics confirmed the hydrophilic nature (LogP, 0.6) and a good absorption capacity (75%) for GA. Data suggests that GA’s antiproliferative activity appears to be related to its antioxidant mechanism, although other mechanisms after its absorption could also be involved.

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Comparative antioxidant scavenging and lipid peroxidation activity of rutin and gallic acid

Cited by 8 publications

References 8 publications

Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats

Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats

Active Biopolymer Coating Based on Sodium Caseinate: Physical Characterization and Antioxidant Activity

Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of ‘Ataulfo’ Mango Peel on LS180 Cells

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