Comparative Assay of HCG, HCT and HCS in Molar Pregnancy

Tojo, Shimpei; Mochizuki, Matsuto; Kanazawa, Satoshi

doi:10.3109/00016347409157754

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Recently, we have detected large amounts of HCT in the serum of patients with molar pregnancies by radioimmunoassay using 131-HCT and anti-HCT serum (6), and suggested that the HCT level was a useful indicator in the treatment of chorionic neoplasm (13).…”

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Hct and Thyroid Function in Molar Pregnancy

Tojo

Kanazawa

Saida

et al. 1976

Acta Obstet Gynecol Scand

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HCT, TSH, T3, T4, PBI, T3-RSU, TBG binding capacity, BMR and thyroid uptake of radioiodine were measured simultaneously on the volunteers with hydatidiform mole and normal pregnancy. TRH stimulation tests were performed on the two groups. The serum HCT levels were higher in association with molar pregnancy than in normal pregnancy. TSH levels were within the nonpregnant range in the two groups. T3, T4, PBI, ETR, BMR and thyroid uptake of radioiodine suggested thyroid hyperfunction in molar pregnancy with a greater degree than that in normal pregnancy. TBG binding capacity and T3-RSU were similar in two groups. The peak TSH levels of TRH stimulation tests ranged widely in patients with molar pregnancies but were within the nonpregnant range in the subjects with normal pregnancies. These findings suggest thyroid hyperfunction in the molar pregnancy is due to a larger amount of HCT than in normal pregnancy.

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confidence: 99%

Hct and Thyroid Function in Molar Pregnancy

Tojo

Kanazawa

Saida

et al. 1976

Acta Obstet Gynecol Scand

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Fetal hemoglobin in women with normal and with hydatidiform molar pregnancy

1982

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The quantity and the rate of synthesis of fetal hemoglobin (HbF); the level of HbF-containing erythrocytes (F cells); and the levels of progesterone, human chorionic gonadotropin (HCG), and human chorionic somatomammotropin (HCS) in serial blood samples from women at different stages of pregnancy were determined. An increase was observed in the synthesis and the quantity of maternal HbF, reaching a peak at about 9-12 weeks gestation. A major peak in F-cell level was also detected at about 9-12 weeks, with two minor peaks appearing at about 16-20 and 22-24 weeks. Levels of HCG, HCS, and progesterone also varied during pregnancy. Timing of the rise and fall of HCG levels corresponded to that of maternal HbF levels, whereas levels of HCS and progesterone did not reach their peak until later stages of gestation when HbF level had returned to normal. Similar analysis conducted on patients with hydatidiform molar pregnancy revealed that the majority (greater than 95%) of these patients showed significant increases in HbF synthesis at the time of molar evacuation, but decreased to normal levels in approximately 30 days post-evacuation. A similar profile in the levels of HCG, but not progesterone and HCS, was observed. A positive correlation between levels of HCG and HbF can be established (correlation coefficient = 0.94). These data are in agreement with the hypothesis that HCG may act as a stimulus for the enhanced HbF synthesis in adults.

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