Comparative assessment of liver fibrosis in patients with HIV/chronic hepatitis C co-infection in different ethnic groups

Abstract

Introduction: In recent years, the frequency of human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection has increased, which is due to their common routes of transmission. HIV/chronic HCV co-infection aggravates the development of fibrosis and increases the risk of cirrhosis. The aim of the study was to evaluate the results of liver elastometry in patients of different ethnic groups with HIV/chronic HCV co-infection. Methodology: The study involved 49 Kazakh and 46 Russian patients with HIV/chronic HCV co-infection. The stage of liver fibrosis was assessed by the results of indirect ultrasonic liver elastometry according to the METAVIR scale using FibroScan 502. As an indirect marker of liver fibrosis, level of alanine aminotransferase and aspartate aminotransferase, as well as platelet counts, were determined. Results: Analysis of the results with the evaluation of the dynamics of fibrotic process in 36 months revealed a prevalence of patients with advanced liver fibrosis (F3, F4) among Kazakh compared with Russian patients, accompanied by a significant increase of liver elasticity indices in Kazakhs and Russians (p < 0.05). Significant differences in the indices of transaminases in the patients with later stages of liver fibrosis (F3, F4) were found (p < 0.05). Conclusions: The study of patients with HIV/chronic HCV co-infection revealed differences in the progression of liver fibrosis depending on ethnicity. Results of elastometry and indirect markers of liver fibrosis were used in the comprehensive assessment at different stages of liver fibrosis.

Increased incidence of cytomegalovirus coinfection in HCV-infected patients with late liver fibrosis is associated with dysregulation of JAK-STAT pathway

“…Understanding the key factors regulating the progression of liver fibrosis in HCV infection is a real challenge. Several studies presented coinfection as a master player in this context 26 , 27 . We explored in our previous studies increased occurrence of CMV coinfection in HCV-patients responding poorly to IFN-based therapeutics 21 and treatment-naïve patients with HCC 22 .…”

“…In this regard, HCV co-infection with other viruses is reasoned to be one of the most important monitoring factors. Recent studies have reported that HCV patients co-infected with HBV or HIV have highly progressive liver diseases and rapidly reach cirrhosis and HCC than HCV mono-infected patients 26 – 28 . However, reports on the coexistence of CMV with HCV are scarce and mainly centering on the role of CMV after liver or kidney transplantation.…”