Comparative Assessment of Liver Tumor Motion Using Cine–Magnetic Resonance Imaging Versus 4-Dimensional Computed Tomography

Fernandes, A.; Apisarnthanarax, Smith; Yin, Lingshu; Zou, W.; Rosen, Mark; Plastaras, John P.; Ben‐Josef, Edgar; Metz, James M.; Teo, Boon K.

doi:10.1016/j.ijrobp.2014.12.048

Cited by 35 publications

(30 citation statements)

References 15 publications

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“…It was found that gated deliveries for radiotherapy of pancreatic cancer is best performed around the end‐exhale position and that motion patterns and motion amplitude differ substantially between individual patients . Cine MRI images have been used to detect larger differences in hepatic intrafraction tumor motion when compared with free breathing 4D CT images most notably in the superior–inferior direction . Cine MRI images may be useful when treating without respiratory management particularly in patients with unreliable 4D CT imaging .…”

Section: Motion In Radiation Therapymentioning

confidence: 99%

“…Cine MRI images have been used to detect larger differences in hepatic intrafraction tumor motion when compared with free breathing 4D CT images most notably in the superior–inferior direction . Cine MRI images may be useful when treating without respiratory management particularly in patients with unreliable 4D CT imaging . Among other factors, the absence of ionizing radiation using MRI has facilitated the application of cine MRI for the development of motion models in several different treatment sites including the abdomen, thorax, liver, breast, and rectum among other sites.…”

Section: Motion In Radiation Therapymentioning

confidence: 99%

“…Cine MRI images may be useful when treating without respiratory management particularly in patients with unreliable 4D CT imaging . Among other factors, the absence of ionizing radiation using MRI has facilitated the application of cine MRI for the development of motion models in several different treatment sites including the abdomen, thorax, liver, breast, and rectum among other sites. The emergence of online MRI‐guided radiation delivery has also permitted the increased utilization of cine MRI techniques for real‐time motion assessment and the construction of motion models …”

Section: Motion In Radiation Therapymentioning

confidence: 99%

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Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

et al. 2017

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The efficacy of stereotactic body radiotherapy (SBRT) has been well demonstrated. However, it presents unique challenges for accurate planning and delivery especially in the lungs and upper abdomen where respiratory motion can be significantly confounding accurate targeting and avoidance of normal tissues. In this paper we review the current literature on SBRT for lung and upper abdominal tumors with particular emphasis on addressing respiratory motion and its affects. We provide recommendations on strategies to manage motion for different, patient specific situations. Some of the recommendations will potentially be adopted to guide clinical trial protocols.

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Section: Motion In Radiation Therapymentioning

confidence: 99%

Section: Motion In Radiation Therapymentioning

confidence: 99%

Section: Motion In Radiation Therapymentioning

confidence: 99%

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Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

et al. 2017

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“…There are several methods for determining liver tumor motion in a simulation process, including four‐dimensional computed tomography (4DCT),4 inhale/exhale breath‐hold CT and cine magnetic resonance imaging (MRI) 5. Due to the density difference between a tumor and the surrounding normal tissue, liver tumors are generally only visible in contrast‐enhanced CT scans.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Liang

Liu

Xue

et al. 2018

J Applied Clin Med Phys

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PurposeTumor motion amplitude varies during treatment. The purpose of the study was to evaluate the intra‐ and interfraction tumor motion and variability in patients with liver cancer treated with fiducial‐based real‐time tracking stereotactic body radiotherapy (SBRT).MethodsFourteen liver patients were treated with SBRT using a CyberKnife. Two to four fiducial markers implanted near the tumor were used for real‐time monitoring using the Synchrony system. The tumor motion information during treatment was extracted from the log files recorded by the Synchrony system. Logfile‐based amplitudes in the superior–posterior (SI), left–right (LR) and anterior–posterior (AP) directions were compared to the 4DCT‐based amplitudes. The intra‐ and interfraction amplitude variations and the incidence of baseline shifts were analyzed for 66 fractions administered to 14 patients.ResultsThe median (range) logfile‐based liver motion amplitudes for all patients were 11.9 (5.1–17.3) mm, 1.3 (0.4–4) mm and 3.8 (0.9–7.7) mm in the SI, LR and AP directions, respectively. Compared with the logfile‐based amplitude, the 4DCT‐based amplitude was underestimated (P < 0.05). The median (range) intra‐ and interfraction liver motion amplitude variations were 4.3 (1.6–6.0) mm (SI), 0.5 (0.2–2.2) mm(LR) and 1.5 (0.3–3.3) mm (AP) and 1.7 (0.5–4.6) mm (SI), 0.3 (0.1–3.0) mm (LR) and 0.7 (0.3–2.7) mm (AP), respectively. Baseline shifts exceeding 2 mm, 3 mm and 5 mm were observed in 27.3%, 7.6% and 3% of the measurements, respectively, within 10 min, and in 66.7%, 38.1% and 19%, respectively, within 30 min for the square root of the sum of the squares of the distances in the SI, LR and AP directions (3D). The tumor motion amplitude was found to be correlated with the baseline shift.ConclusionsMost patients showed significant intra‐ and interfraction liver motion amplitude variations over the entire course of radiation. More caution is needed for patients with large tumor motion amplitudes.

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“…Contrary to this, MRI allows image acquisition in any image orientation (i.e. axial, sagittal and coronal) and an optimal scan direction can be chosen as needed to potentially obtain more accurate measurement of tumour motion and range . MRI also provides superior soft‐tissue contrast required for precise tumour delineation in conventional radiotherapy and tumour tracking in MR‐guided radiotherapy (i.e.…”

Section: Introductionmentioning

confidence: 99%

A retrospective 4D‐MRI based on 2D diaphragm profiles for lung cancer patients

et al. 2019

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Introduction 4D‐MRI, compared to 4D‐CT, provides better soft‐tissue contrast for target delineation. However, motion artefacts are often observed due to residual breathing variations. This study is to present a retrospective 4D‐MRI reconstruction method based on 2D diaphragm profiles to improve the quality of 4D‐MR images in the presence of significant breathing variations. Methods The proposed 4D‐MRI reconstruction method utilized diaphragm profiles (2D cine images on a single sagittal plan at the peak diaphragm) in conjunction with 4D‐MR scans (2D‐cine images on multiple pre‐determined coronal planes along the anterior‐posterior direction over a volume of interest). The diaphragm profile images were exploited to sort the 4D‐MR scans by matching respiratory amplitude of diaphragm on the 4D‐MR scans to the diaphragm profiles. To evaluate reconstructed 4D‐MR images (ten 3D‐MR images), sagittal images on ten 3D‐MR images under free breathing (FB) and respiratory guidance (GB) were compared with diaphragm profile images (reference) from 13 healthy volunteers. Results Forty‐four 4D‐MR scan datasets were successfully reconstructed without distinct respiratory‐related motion artefacts even with the presence of breathing variation. The differences in diaphragm profiles between the reference and corresponding reconstructed images in the mean of root mean square were similar between FB (3.5 mm) and GB (3.0 mm), confirming that the 4D‐MRI reconstruction method was effective even with significant breathing variation. Conclusions The diaphragm profiles were utilized to reconstruct 4D‐MR images with spatial reliability and a fixed scan time under FB and GB. Our method can provide reliable 4D information of thoracic and abdominal regions for MRI‐guided radiotherapy.

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Comparative Assessment of Liver Tumor Motion Using Cine–Magnetic Resonance Imaging Versus 4-Dimensional Computed Tomography

Cited by 35 publications

References 15 publications

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

A retrospective 4D‐MRI based on 2D diaphragm profiles for lung cancer patients

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