Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Новиков, М. А.; Титов, Е. А.; Соседова, Л. М.; Рукавишников, В. С.; Vokina, Vera A.; Лахман, О. Л.

doi:10.3390/ijms222413257

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The choice of dose is due to previous studies of the toxic properties of nanocomposites of other metals (Ag, Bi, Fe, etc.) [ 28 , 29 , 30 , 31 , 32 , 33 ], indicating the development of clear and persistent signs of pathology with the introduction of this dose. Control animals ( n = 10) received 1 mL of distilled water in the same mode.…”

Section: Methodsmentioning

confidence: 99%

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

et al. 2022

Self Cite

View full text Add to dashboard Cite

The acute and subacute toxicity of a newly synthesized silver selenide nanoparticles encapsulated in a natural polymeric matrix of arabinogalactan study has been studied. The nanocomposite is a promising material for the design of diagnostic and therapeutic drugs. It can also be used for the preparation of fluorescent labels and in thermal oncotherapy. The employment of binary nanocomposites enables one to unveil the potential hidden in metals which constitute these composites. The study of acute toxicity, carried out by the oral administration of nanocomposites at a dose of 2000 mg/kg, has shown that the compound belongs to low-toxic substances of the 5th hazard class. With the subacute oral administration of nanocomposites at a dose of 500 μg/kg, slight changes are observed in the brain tissue and liver of experimental animals, indicating the development of compensatory–adaptive reactions. In the kidneys, the area of the Shumlyansky–Bowman chamber decreases by 40.5% relative to the control group. It is shown that the application of the protective properties of selenium, which is contained in the composite, helps to reduce the toxicity of silver.

show abstract

Section: Methodsmentioning

confidence: 99%

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Outcomes related to physical, chemical and biological effects will allow us to solve most diagnostic and therapeutic tasks [ 14 , 15 , 16 ]. Novikov et al [ 17 ] carry out a comparative assessment of the biological effects of silver nanoparticles encapsulated in natural and synthetic stabilizing polymer matrices and reveal the features of their effects. Pathological abnormalities expressed in the structure of the temporoparietal zone of the sensorimotor cortex of the rat brain, increasing over time, are found in the nanobiocomposites of silver nanoparticles and the natural polysaccharide arabinogalactan.…”

mentioning

confidence: 99%

Toxicology, Nanotoxicology and Occupational Diseases Related to Chemical Exposure

Sutunkova

2022

IJMS

View full text Add to dashboard Cite

show abstract

Assessment of neurotoxicity of gadolinium nanocomposite

Novikov,

Titov,

Yakimova

et al. 2024

Hygiene and Sanitation

View full text Add to dashboard Cite

Introduction. A promising area of nanotoxicology is the study of the effects of gadolinium nanoparticles on a living organism, which will allow achieving high image contrast when performing MRI with a significantly smaller amount of the injected substance. This is possible using high-molecular compounds, for example, arabinogalactan of Siberian larch, which has a stabilizing effect for nanoparticles. Materials and methods. Experimental studies were performed on ninety six mongrel white male rats weighing 180–240 g, divided into 3 groups (one control and two experimental). A water-based solution was used as the exposed substance, which included gadolinium nanoparticles, as well as a nanostabilizing matrix – the natural polysaccharide arabinogalactan. The solution was administered orally for 10 days in two doses – 500 and 5000 mcg of gadolinium per 1 kg of animal body weight. After the introduction, some of the animals were withdrawn from the experiment and made up the early examination period, the remaining part of the animals were left to survive for 6 months and made up the long-term examination period, and subsequently were also withdrawn from the experiment. The work used a set of studies aimed at determining neurotoxicity – the “Open Field” test, EEG examination, morphological and morphometric methods. Results. The structural and functional features of the effect of gadolinium nanocomposite on the central nervous system were expressed in an increase in the number of degeneratively altered neurons when administered a solution at a dose of 500 mcg of gadolinium per 1 kg of animal body weight in the early period of examination, while indices reflecting approximate research activity, behaviour and EEG indices, compared with the control, did not changed. Limitations. When studying the effects of gadolinium nanoparticles encapsulated in the polysaccharide arabinogalactan on 96 outbred male rats, which is sufficient to use a set of methods to determine the functional state of the central nervous system and structural changes in nervous tissue. Conclusion. Thus, the subacute effect of gadolinium nanoparticles encapsulated in the arabinogalactan matrix causes structural changes in the nervous tissue, while functional changes in the central nervous system were not observed.

show abstract

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Cited by 3 publications

References 30 publications

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

Toxicology, Nanotoxicology and Occupational Diseases Related to Chemical Exposure

Assessment of neurotoxicity of gadolinium nanocomposite

Contact Info

Product

Resources

About