Multimegawatt horizontal axis wind turbines often operate in yawed wind transients, in which the resulting periodic loads acting on blades, drive-train, tower, and foundation adversely impact on fatigue life. Accurately predicting yawed wind turbine aerodynamics and resulting structural loads can be challenging and would require the use of computationally expensive high-fidelity unsteady Navier-Stokes computational fluid dynamics. The high computational cost of this approach can be significantly reduced by using a frequency-domain framework. The paper summarizes the main features of the COSA harmonic balance Navier-Stokes solver for the analysis of open rotor periodic flows, presents initial validation results on the basis of the analysis of the NREL Phase VI experiment, and it also provides a sample application to the analysis of a multimegawatt turbine in yawed wind. The reported analyses indicate that the harmonic balance solver determines the considered periodic flows from 30 to 50 times faster than the conventional time-domain approach with negligible accuracy penalty to the latter. KEYWORDS harmonic balance Navier-Stokes equations, horizontal axis wind turbine aerodynamics, NREL Phase VI wind turbine, NREL 5 MW wind turbine, yawed wind aerodynamics 1 INTRODUCTION Wind energy is a key low-carbon energy source, playing a crucial role in lowering global greenhouse gas emissions, and it is now viewed as one of the most cost-effective climate change mitigation technologies. Current utility-scale horizontal axis wind turbines (HAWTs) already feature fairly high aerodynamic efficiencies; however, because of the spatial and temporal variability of the environmental conditions, HAWTs often experience unsteady flow conditions, which induce fatigue and lower the energy harvest. Several of such regimes can be viewed as periodic, and typical examples include the blades rotating (a) through stratifications of the atmosphere associated with the atmospheric boundary layer, with the wind velocity varying by as much as 6 m/s over a 100-m rotor diameter, 1 (b) through the variable pressure field due to the downwind tower, and (c) in yawed wind, occurring when the freestream wind velocity is no longer orthogonal to the turbine rotor. 2 In all these cases, the fundamental frequency of the periodic excitation is a multiple of the rotor speed.Regarding yawed wind, utility-scale HAWTs typically feature yaw control systems that monitor the wind direction and turn the entire nacelle to realign wind and rotor normal. 2 Yaw actuators, however, adjust the nacelle position after a relatively long time interval from the yaw misalignment detection, and thus, fatigue due to yaw misalignment can be significant. The yawed wind condition also reduces the power produced by the turbine, and the reduction increases nonlinearly with the cosine of the yaw misalignment. Above certain wind speed-and turbine-dependent yaw misalignment thresholds, dynamic stall also occurs, and this aggravates further unsteady loads because of hysteretic force and mom...