Comparative bioactivity profile of phospholipids from three marine byproducts based on the zebrafish model

Xie, Dongxiao; Li, Peihai; Zhu, Yongqiang; He, Junwei; Zhang, Mengqi; Liu, Kechun; Lin, Hou‐Wen; Zhai, Hongbin; Li, Xiaobin; Ma, Yong

doi:10.1111/jfbc.14229

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…Finally, it is important to highlight that, more than just a potential to display beneficial effects based on their composition, some lipid fractions from marine animal co-products have in fact been ascribed interesting biological activities. Phospholipid extracts from shrimp heads, codfish roe, and squid gonads were tested for their antithrombotic, antistroke, anti-inflammatory, pro-angiogenic, and cardioprotective activities, with promising results [230]. Another study highlighted the anti-inflammatory activities of extracts from gloomy octopus (Octopus tetricus) viscera, squid (Sepioteuthis australis) heads, Australian sardine (Sardinops sagax) viscera/heads, salmon (S. salar) heads, and school prawn (Penaeus plebejus) viscera/heads [169].…”

Section: The Value Of Marine Animal Co-product Lipids For Various Ind...mentioning

confidence: 99%

“…Lipids from co-products of marine animals may also be appealing to the fields of pharmacology and drug development. As previously mentioned, phospholipid extracts from co-products derived from fish, crustaceans, and mollusks have been shown to display interesting biological activities, and have therefore been suggested as possible targets for pharmacological and clinical studies and development, namely in the context of inflammatory and cardiovascular diseases [230]. Moreover, phospholipids have also attracted interest as drug delivery systems on the basis of their excellent biocompatibility and amphiphilicity [259,260].…”

Section: The Value Of Marine Animal Co-product Lipids For Various Ind...mentioning

confidence: 99%

See 1 more Smart Citation

Marine Animal Co-Products—How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Monteiro,

Domingues,

Calado

2024

Marine Drugs

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Marine lipids are recognized for their-health promoting features, mainly for being the primary sources of omega-3 fatty acids, and are therefore critical for human nutrition in an age when the global supply for these nutrients is experiencing an unprecedent pressure due to an ever-increasing demand. The seafood industry originates a considerable yield of co-products worldwide that, while already explored for other purposes, remain mostly undervalued as sustainable sources of healthy lipids, often being explored for low-value oil production. These co-products are especially appealing as lipid sources since, besides the well-known nutritional upside of marine animal fat, which is particularly rich in omega-3 polyunsaturated fatty acids, they also have interesting bioactive properties, which may garner them further interest, not only as food, but also for other high-end applications. Besides the added value that these co-products may represent as valuable lipid sources, there is also the obvious ecological upside of reducing seafood industry waste. In this sense, repurposing these bioresources will contribute to a more sustainable use of marine animal food, reducing the strain on already heavily depleted seafood stocks. Therefore, untapping the potential of marine animal co-products as valuable lipid sources aligns with both health and environmental goals by guaranteeing additional sources of healthy lipids and promoting more eco-conscious practices.

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Section: The Value Of Marine Animal Co-product Lipids For Various Ind...mentioning

confidence: 99%

Section: The Value Of Marine Animal Co-product Lipids For Various Ind...mentioning

confidence: 99%

Marine Animal Co-Products—How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Monteiro,

Domingues,

Calado

2024

Marine Drugs

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show abstract

“…Collectively, these studies further highlight the role that both PAF and its metabolism play in atherosclerosis and the role that future fish PL-based therapeutics may play in the battle against CVD. Indeed, multiple studies have demonstrated potential antiplatelet properties of fish oil PLs in vitro against PAF and various platelet agonists [137][138][139][150][151][152] and in various models of CVD in vivo [145,153]. However, it should be noted that PL sources characterized by lower levels of n-3 PUFAs such as dairy and meat also exhibit antiplatelet effects to a similar extent [21,154,155], indicating the promise of developing PL-based therapeutics generally.…”

Section: Marine Oil Polar Lipids: Innovations and Human Healthmentioning

confidence: 99%

Cardiovascular Diseases and Marine Oils: A Focus on Omega-3 Polyunsaturated Fatty Acids and Polar Lipids

Caffrey,

Leamy,

O’Sullivan

et al. 2023

Marine Drugs

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Cardiovascular diseases (CVD) remain the leading cause of death across the globe, hence, establishing strategies to counteract CVD are imperative to reduce mortality and the burden on health systems. Dietary modification is an effective primary prevention strategy against CVD. Research regarding dietary supplementation has become increasingly popular. This review focuses on the current in vivo, in vitro, and epidemiological studies associated with that of omega-3 polyunsaturated fatty acids (n-3 PUFAs) and polar lipids (PLs) and how they play a role against CVD. Furthermore, this review focuses on the results of several major clinical trials examining n-3 PUFAs regarding both primary and secondary prevention of CVD. Notably, we place a lens on the REDUCE-IT and STRENGTH trials. Finally, supplementation of PLs has recently been suggested as a potential alternative avenue for the reduction of CVD incidence versus neutral forms of n-3 PUFAs. However, the clinical evidence for this argument is currently rather limited. Therefore, we draw on the current literature to suggest future clinical trials for PL supplementation. We conclude that despite conflicting evidence, future human trials must be completed to confirm whether PL supplementation may be more effective than n-3 PUFA supplementation to reduce cardiovascular risk.

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“…Finally, it is important to highlight that, more than just a potential to display beneficial effects based on their composition, some lipid fractions from marine animal co-products have in fact been ascribed interesting biological activities. Phospholipid extracts from shrimp heads, codfish roe, and squid gonads were tested for their antithrombotic, anti-stroke, anti-inflammatory, pro-angiogenic, and cardioprotective activities with promising results [214]. Another study highlighted the antiinflammatory activities of extracts from gloomy octopus (Octopus tetricus) viscera, squid (Sepioteuthis australis) heads, Australian sardine (Sardinops sagax) viscera/heads, salmon (S. salar) heads and school prawn (Penaeus plebejus) viscera/heads and [152].…”

Section: The Value Of Marine Animal Co-product Lipids For Human Healthmentioning

confidence: 99%

“…Lipids from co-products of marine animals may also be appealing to the fields of pharmacology and drug development. As previously mentioned, phospholipid extracts from co-products derived from fish, crustaceans and mollusks have been shown to display interesting biological activities, and therefore suggested as possible targets for pharmacological and clinical studies and development, namely in the context of inflammatory and cardiovascular diseases [214]. Moreover, phospholipids have also attracted interest as drug delivery systems on the basis of their excellent biocompatibility and amphiphilicity [239,240].…”

Section: The Value Of Marine Animal Co-product Lipids For Industrymentioning

confidence: 99%

Marine Animal Co-Products – How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Monteiro,

Domingues,

Calado

2023

Preprint

View full text Add to dashboard Cite

Marine lipids are recognized for their health promoting features, mainly for being the primary sources of omega-3 fatty acids, and therefore critical for human nutrition in an age when the global supply for these nutrients is experiencing an unprecedent pressure due to an ever-increasing demand. The seafood industry originates a considerable yield of co-products worldwide that, while already explored for other purposes, remain mostly undervalued as sustainable sources of healthy lipids, often being explored for low value oil production. These co-products are especially appealing as lipid sources since, besides the well-known nutritional upside of marine animal fat, particularly rich in omega-3 polyunsaturated fatty acids (PUFAs), they have also interesting bioactive properties, which may garner them further interest, not only as food, but also for other high-end applications. Besides the added value that these co-products may represent as valuable lipid sources, there is also the obvious ecological upside of reducing seafood industry waste. In this sense, repurposing these bioresources will contribute to a more sustainable use of marine animal food, reducing the strain on already heavily depleted seafood stocks. Therefore, untapping the potential of marine animal co-products as valuable lipid sources aligns with both health and environmental goals by guaranteeing additional sources of healthy lipids and promoting more eco-conscious practices.

show abstract

Comparative bioactivity profile of phospholipids from three marine byproducts based on the zebrafish model

Cited by 7 publications

References 43 publications

Marine Animal Co-Products—How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Marine Animal Co-Products—How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

Cardiovascular Diseases and Marine Oils: A Focus on Omega-3 Polyunsaturated Fatty Acids and Polar Lipids

Marine Animal Co-Products – How Improving Their Use as Rich Sources of Health-Promoting Lipids Can Foster Sustainability

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