Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages

Sümer, Engin; Şentürk, Gözde Erkanlı; Demirel, Ozlem Unay; Yeşilada, Erdem

doi:10.1016/j.jep.2019.112458

Cited by 21 publications

(21 citation statements)

References 46 publications

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“…Histopathological examination of formalin-fixed kidney and liver tissues was carried out according to a previous study. 27 Briefly, kidney and liver tissues were dehydrated with a gradient series of ethanol solutions and rinsed with xylene 3 times. Then, fixed tissues were placed in a mold that contained a small amount of molten paraffin.…”

Section: Methodsmentioning

confidence: 99%

In VitroandIn VivoAntimalarial Activities and Toxicological Assessment ofPogostemon Cablin(Blanco) Benth

Phuwajaroanpong

Chaniad

Horata

et al. 2020

J Evid Based Complementary Altern Med

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The aim of this study was to investigate the antimalarial activities and toxicity of Pogostemon cablin extracts. In vitro activities against the chloroquine-resistant Plasmodium falciparum K1 strain were assessed by using the Plasmodium lactate dehydrogenase enzyme (pLDH) assay, while in vivo activity against the Plasmodium berghei ANKA strain in mice was investigated using a 4-day suppressive test. The in vitro and in vivo toxicity were determined in Vero cells and mice, respectively. The ethanolic extract possessed antimalarial activity with an IC50 of 24.49 ± 0.01 µg/ml, whereas the aqueous extract showed an IC50 of 549.30 ± 0.07 µg/ml. Cytotoxic analyses of the ethanolic and aqueous extracts revealed a nontoxic effect on Vero cells at a concentration of 80 µg/ml. Based on a preliminary study of in vitro antimalarial activity, the ethanolic extract was chosen as a potential agent for further in vivo antimalarial activity analysis in mice. The ethanolic extract, which showed no toxic effect on mice at a dose of 2000 mg/kg body weight, significantly suppressed parasitemia in mice by 38.41%, 45.12% and 89.00% at doses of 200, 400 and 600 mg/kg body weight, respectively. In conclusion, this study shows that the ethanolic P. cablin extract possesses in vitro and in vivo antimalarial activity without toxic effects.

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Section: Methodsmentioning

confidence: 99%

In VitroandIn VivoAntimalarial Activities and Toxicological Assessment ofPogostemon Cablin(Blanco) Benth

Phuwajaroanpong

Chaniad

Horata

et al. 2020

J Evid Based Complementary Altern Med

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“…The agri-food industry generates millions of tons of waste each year, leading to serious environmental problems and a loss of valuable compounds [ 1 ]. Artichoke ( Cynara scolymus L.) is used as food and as a traditional remedy [ 2 , 3 ], and large amounts of waste (about 80–85% of the total plant biomass) are generated during industrial processing. Over the last years, attempts have been made to find possible uses for artichoke by-products (bracts, leaves, and stems) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Methanol, ethanol, and water have been used for the extraction of sugar and phenolics from bracts [ 3 , 5 , 8 , 9 ]. Ultrasound-assisted extraction with water [ 12 ] and also with 60% methanol [ 6 ] enhanced the extraction of phenolics and prebiotic fructans [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Valorization of Artichoke Industrial By-Products Using Green Extraction Technologies: Formulation of Hydrogels in Combination with Paulownia Extracts

et al. 2021

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The integral valorization of artichoke bracts generated during industrial canning of artichoke was assessed. The extraction of bioactive compounds was addressed with pressurized hot water under subcritical conditions. The performance of this stage on the extraction of phenolics with antioxidant properties and the saccharidic fraction using conventional and microwave heating was compared. The microwave assisted process was more efficient than the conventional one regarding extraction yields of total solubles, and glucose and fructose oligomers and phenolics, because lower operational temperatures and shorter times were needed. Degradation of fructose oligomers was observed at temperatures higher than 160 °C, whereas the maximal phenolic content occurred at 220 °C. Both the extracts and the residual solids, obtained at conditions leading to maximum phenolics yields, were evaluated for the production of starch-based hydrogels, supplemented with Paulownia leaves’ aqueous extracts.

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“…No estudo de (Sümer et al, 2020), analisaram a capacidade do extrato da alcachofra em ser hepatoprotetor e nefroprotetor. Assim, ratos foram induzidos experimentalmente com paracetamol, e quando foram tratados com as hastes e reptáculo da alcachofra houve melhora dos exames histopatológicos do fígado e rins.…”

Section: Aumento Da Eliminação Renalunclassified

“…Assim, ratos foram induzidos experimentalmente com paracetamol, e quando foram tratados com as hastes e reptáculo da alcachofra houve melhora dos exames histopatológicos do fígado e rins. Segundo o mesmo autor os marcadores séricos aumentado de BUN e creatinina após induzidos pelo paracetamol, foram melhorados com extrato da alcachofra (Sümer et al, 2020). Segundo Pires, (2017) os rins apresentam co-transportador de sódio-glicose (SGLT-2) que reabsorve a maior parte da glicose renal.…”

Section: Aumento Da Eliminação Renalunclassified

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Oliveira

Domingueti

Santos

et al. 2021

RSD

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O diabetes mellitus gera um grave problema ao sistema de saúde e aos indivíduos, sendo caracterizado por um distúrbio crônico, que afeta o metabolismo de carboidratos, gorduras e proteínas. O presente estudo tem por objetivo realizar uma revisão de literatura demonstrando os mecanismos de ação da alcachofra no controle glicêmico. Foi efetuada uma busca eletrônica noScielo, Pubmed,Science direct e Google Scholar, comparando as diferentes informações encontradas nestas plataformas, listando os mecanismos de ação da alcachofra no controle glicêmico no diabetes mellitus. Foram levantados 63 artigos científicos na língua portuguesa, inglesa e espanhola, dos quais 17,5% abordaram sobre a alcachofra sua composição, conteúdos fenólicos e efeitos anti-hiperglicêmicos, 13 % descrevem sobre os polifenóis, flavonoides e sua ação anti hiperglicêmica, 16 % relata sobre a regulação da α-glicosidase, 6% aborda sobre o transporte de glicose via GLUT; 6% sobre a secreção de insulina pelas células beta pancreáticas, 13% relata a regulação do metabolismo de glicose hepática, 11 % relata a eliminação renal de glicose, 9,5% sobre o diabetes e suas complicações e 8% aborda outras plantas e compostos naturais com ação semelhante a alcachofra. De acordo com resultados a possível ação da alcachofra e seus metabólitos especiais está na inibição da alfa-glicosidase, e acrescentar sua importante ação na redução dos radicais livre, redução do glucagon, manutenção hepática do metabolismo glicêmico, proteção das células beta-pancreática, aumento nos níveis de insulina, e captação de glicose nos tecidos, sendo importante fatores na homeostase glicêmica. Por outro lado, a utilização de flavonoides é um dos alvos mais utilizados pela literatura no controle glicêmico a médio e longo prazo. Com a presente revisão é possível concluir que todas as vias mencionadas acima, torna-se algo promissor na busca por tratamento complementar do controle glicêmico de indivíduos portadores do diabetes mellitus.

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Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages

Cited by 21 publications

References 46 publications

In VitroandIn VivoAntimalarial Activities and Toxicological Assessment ofPogostemon Cablin(Blanco) Benth

In VitroandIn VivoAntimalarial Activities and Toxicological Assessment ofPogostemon Cablin(Blanco) Benth

Valorization of Artichoke Industrial By-Products Using Green Extraction Technologies: Formulation of Hydrogels in Combination with Paulownia Extracts

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

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