Comparative bone morphometric analysis of mandibles and 2nd metacarpals

Wowern, Nina Von; Stoltze, Kaj

doi:10.1111/j.1600-0722.1979.tb00694.x

Cited by 17 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…showed an increased remodeling [16][17][18][19][20][21], a decrease in bone volume of the mandible [22] and cancellous bone loss in the mandibular condyle [23]. The estrogen deficiency-induced osteoporosis appears to be a result of the binding of the receptor activator of the nuclear factor B (RANK) and RANK ligand (RANKL), as previously reported [24][25][26].…”

Section: Introductionmentioning

confidence: 63%

“…Thus, reduced-sclerostin did not appear to be associated with diminished ER in osteocytes in the mesial region. Other studies suggested a proapoptotic effect of estrogens on osteoclasts and osteoblasts [43,44], and therefore, it was necessary to confirm whether the reduced amount of sclerostin would be It is well known that OVX stimulates osteoclastic differentiation and subsequent bone resorption in long bones, and also shows the similar effects in alveolar bone [16][17][18][19][20][21][22].…”

Section: Immunolocalization Of Er and Tunel-positive Osteocytes In Tmentioning

confidence: 99%

See 1 more Smart Citation

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo

Liu

et al. 2012

Journal of Electron Microscopy

View full text Add to dashboard Cite

This study aimed to elucidate whether estrogen deficiency would affect the synthesis of an osteocyte-derived factor, sclerostin, in the mesial region of alveolar bone. Eight 9-week-old Wister female rats were ovariectomized (OVX), and the other eight rats were Sham-operated (Sham). After 4 weeks, the interradicular septa of mandibular first molar were embedded in paraffin, and then, were histochemically examined. Sclerostin-positive osteocytes were located in a superficial layer of the mesial region of Sham bone, while the OVX mesial region showed a lesser presence of the sclerostin-reactive osteocytes. There was no significant difference in the distribution of estrogen receptor  and TUNEL-positive cells in either Sham or OVX groups. Meanwhile, the Sham mesial region demonstrated many osteoclasts, but the OVX specimens showed numerous osteoclasts in association with intense immunolabeling of the receptor activator of the nuclear factor kB ligand. Complex meshwork of cement lines was seen consistent with irregularly-distributed osteocytic lacunar-canalicular system in the OVX mesial region, compared with those of the Sham specimens. In conclusion, estrogen deficiency appears to inhibit osteocytes for sclerostin synthesis in the mesial region of the interradicular septum, mediated by accelerated bone remodeling, rather than by directly effecting osteocytes. words

show abstract

Section: Introductionmentioning

confidence: 63%

Section: Immunolocalization Of Er and Tunel-positive Osteocytes In Tmentioning

confidence: 99%

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo

Liu

et al. 2012

Journal of Electron Microscopy

View full text Add to dashboard Cite

show abstract

“…36 Using yet another metacarpal index, other investigators found significant correlations between the index and mandibular cortical porosity and cortical width for forty male and female cadavers (20 to 90 years of age). 37 In a two article series (1974), specific gravity analysis (as determined by water displacement), dual-beam Xray analysis, and activation analysis indicated that for 50 cadaver mandibles and radii (1) there were significant decreases in densities with age, (2) the densities in the mandibles were significantly correlated with those of radii, and (3) the densities of female mandibles were significantly lower (by 8%) than those for males. 38 · 39 Single photon absorptiometry (SPA), which was introduced in 1963 and uses 125-iodine as an energy source, 40 was employed in 1977 to determine forearm bone mineral content (BMC) in 15 patients with juvenile periodontitis and fifteen controls.…”

Section: Osteoporosis and Oral Bone Lossmentioning

confidence: 95%

Osteoporosis and oral bone loss.

Hildebolt

1997

Dentomaxillofacial Radiology

174

View full text Add to dashboard Cite

This paper is a review of the literature on the possible association between osteoporosis and oral bone loss, with an emphasis on radiological studies. Such an association was first suggested in 1960. Subsequent histomorphometric and microradiographic studies showed that after the age of 50 there was a marked increase in the cortical porosity of the mandible, with this increase being greater in the alveolar bone than the mandibular body; and that with this increase in porosity, there was a concomitant decrease in bone mass, which appeared to be more pronounced in females than in males, with the loss in bone mineral content estimated to be 1.5% per year in females and 0.9% in males. These studies also demonstrated a considerable amount of variation in the amounts of cortical and trabecular bone within and among individuals. Subsequent clinical studies reported associations between the bone densities of jaws and (1) metacarpals, (2) forearm bones, (3) vertebrae and (4) femurs. These studies indicated that women had lower mandibular bone mineral content (BMC) than men and that age-related loss of bone was more pronounced in women after the age of 50 years than in men of the same age, as was the case for the rest of the body. It was suggested that systemic factors responsible for osteoporotic bone loss may combine with local factors (periodontal diseases) to increase rates of periodontal alveolar bone loss. Although not all studies found associations between osteoporosis and oral bone loss, the conclusion of this review is that such an association exists; yet additional longitudinal investigations are needed to confirm this, and before the implications of this association could be fully utilized in clinical dentistry, inexpensive methods must be developed for sensitive and specific measures of oral bone loss.

show abstract

“…Several investigators [6][7][8][9][10][11] have also reported a positive correlation between the general skeletal bone mass or bone mineral density (BMD) and the mandibular bone mass in postmenopausal women. Von Wowern and Storze 7 demonstrated by bone morphometry that the buccal cortical bone mass of the mandible was significantly correlated with the metacarpal index.…”

mentioning

confidence: 98%