Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells

Wang, Xi; Sha, Xin-Jia; Li, Guanghui; Yang, Fang; Ji, Kun; Wen, Lu; Liu, Shiyu; Chen, Lei; Ding, Yin; Xuan, Kun

doi:10.1016/j.archoralbio.2012.02.014

Cited by 164 publications

(138 citation statements)

References 37 publications

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“…(38) Ancak SHEDs ve DPSCs aynı kökenden gelmelerine rağmen diferansiyel eğilim-lerinde farklılıklar görülmüştür. 19,37,38 SHEDs'nin DPSCs'ne göre daha yüksek pluripotent marker elde edilerek kendi kökenlerinden gelen hücrelere diferansiye olma eğilimlerinin daha fazla olduğu tespit edilmiştir. Buna rağmen DPSCs'de daha fazla nöroepitelyal kök hücre markerleri bulunmuştur.…”

Section: Düşen Süt Di̇şi̇ Kök Hücreleri̇(sheds)unclassified

Dental Kök Hücreler Ve Süt Di̇şleri̇ni̇n Kök Hücre Çalişmalarindaki̇ Önemi̇

Ünsal¹,

Özmekik²,

Ulukapi³

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Stem cells are fundemental cells that have charecteristics of self-renewal and being divided unlimitedly, and generate tissue and organs. Dental stem cells have taken place among the postnatal stem cell sources as they are easy to get and require minimally invasive process. Multipotent stem cells in dental pulp, apical papilla, periodontal ligament, dental follicle and decidious teeth are isolated. It is determined that stem cells from human exfoliated decidious teeth differantiate to neurons, adipocytes, chondrocytes, osteoblasts and odontoblasts, and it is reported that they can be alternative stem cell source at autolog stem cell based therapy.

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Section: Düşen Süt Di̇şi̇ Kök Hücreleri̇(sheds)unclassified

Dental Kök Hücreler Ve Süt Di̇şleri̇ni̇n Kök Hücre Çalişmalarindaki̇ Önemi̇

Ünsal¹,

Özmekik²,

Ulukapi³

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…These results suggested that SHED possessed the potential not only to differentiate into endothelial cells but also to induce the differentiation of endothelial cells that were located around them. When subcutaneously transplanted into immunocompromised mice, SHED showed the capacity to produce bone-like structures on the surface of ceramic bovine bone scaffolds [39]. SHED also exhibited the potential to differentiate into odontoblasts and endothelial cells and, consequently, promoted the formation of dentin and microvessels; SHED cultured in tooth root complexes that were composed of the roots of human premolars within nanofiber hydrogel or collagen scaffolds upregulated the expression of dentin-related genes in vitro [45].…”

Section: Exfoliated Deciduous Teethmentioning

confidence: 99%

“…SHED are particularly attractive sources of stem cells because they can be isolated noninvasively from naturally exfoliated deciduous teeth. SHED have been shown to express the MSC-related cell surface markers, CD13, CD29, CD44, CD73, CD90, CD105, CD146, CD166, and STRO-1 [37][38][39]. SHED expressed high levels of the growth factors, basic fibroblast growth factor (bFGF), connective tissue growth factor (CTGF), transforming growth factor (TGF)-β2, and TGF-β3, compared with DPSC [40].…”

Section: Exfoliated Deciduous Teethmentioning

confidence: 99%

Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

Tomokiyo

Hynes

Gronthos

et al. 2015

Curr Oral Health Rep

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“…Miura et al (4) successfully isolated stem cells from human exfoliated deciduous teeth (SHED) and identified that they had the general characteristics of DPSCs. Wang et al (5) also isolated SHED and found that their capability of mineralization and mRNA expression levels of inflammatory cytokines were higher compared with those of DPSCs (5). Furthermore, Kerkis and Caplan (6) described that the derivation of induced pluripotent stem (iPS) cells from DPSCs was significantly more efficient compared with that of human fibroblasts.…”

Section: Introductionmentioning

confidence: 99%

Derivation and growth characteristics of dental pulp stem cells from patients of different ages

Zhou

et al. 2015

Molecular Medicine Reports

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Abstract. The dental pulp contains a relatively low number of stem cells; however, it is considered to be a promising source of stem cells for use in regenerative therapy. To date, it has remained elusive whether there are certain differences in the dental pulp stem cells (DPSCs) from donors of different ages. In the present study, DPSC lines were derived using teeth from children, adolescents, adults and aged donors. The derivation efficiency, the proliferative and apoptotic rate, cell marker expression and the differentiation capacity were investigated and compared among these DPSC lines. The derivation efficacy was decreased with increasing donor age. Although a large part of cell surface markers was expressed in all DPSC lines, the expression of CD29 was downregulated in the DPSCs from aged teeth. In addition, the doubling time of DPSCs from aged teeth was prolonged and the number of apoptotic cells was increased with the propagation. These DPSCs were able to differentiate into a neuronal linage, which positively expressed the neuron-specific class III beta-tubulin and microtubule-associated protein 2, as well as into an osteogenic lineage, which positively expressed CD45; however, these DPSCs from aged teeth were completely or partially deprived of differentiation capacity. By contrast, DPSCs from younger teeth displayed significantly higher vitality and a higher potential for use in dental regenerative medicine.

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Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells

Cited by 164 publications

References 37 publications

Dental Kök Hücreler Ve Süt Di̇şleri̇ni̇n Kök Hücre Çalişmalarindaki̇ Önemi̇

Dental Kök Hücreler Ve Süt Di̇şleri̇ni̇n Kök Hücre Çalişmalarindaki̇ Önemi̇

Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

Derivation and growth characteristics of dental pulp stem cells from patients of different ages

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