Comparative chemical composition of Agastache mexicana subsp. mexicana and A. mexicana subsp. xolocotziana

Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents

“…The ethyl acetate extract was the most active to reduce nociception followed by the hexane extract. Previous phytochemical screening of Agastache species has characterized the abundant presence of ursolic acid in the ethyl acetate extract and pulegone in the hexane extract, less important presence of oleanolic acid has been shown in both (Estrada-Reyes et al, 2004;Verano-Blas and Corté s-Zamora, 2010). Several pharmacological studies on ursolic acid have described the antinociceptive (Kang et al, 2008) and anti-inflammatory properties of this triterpene (Safayhi et al, 1997;Najid et al, 1992;Ferrer et al, 2005).…”

“…2F). Several constituents of flavonoid nature have been characterized in the methanol extract, essentially acacetin and tilianin (Estrada-Reyes et al, 2004). Flavonoids are well known effective natural anti-inflammatory agents (Ueda et al, 2004) that can produce antispasmodic effect as well (Yonathan et al, 2006).…”

Antidepressant-Like Effects of Dracocephalum moldavica L. in Mouse Models of Immobility Tests

“…In our case we focus on the use of polar solvents, because they favour the accumulation on flavonoids which as it has been well establish have a therapeutic effect on the Central Nervous System (CNS). [9][10][11][12] Thus, the abundance of the According to Estrada-Reyes et al, 29 the biological action of flavonoids has been attributed to their antioxidant properties; mainly due to the chelating potential that gives them their chemical structure, in such a way that the antioxidant activity can be due to their reducing capacities per se or to influence the oxidation-reduction (redox) intracellular state. 30 Additionally, they exert neuroprotective effects in cells and animal models through different biological processes such as the attenuation of oxidative stress.…”

“…[9][10][11] The presence of this type of compounds in Agastache species could be related to their therapeutic effects. 12 However, the use of these two plants has not been studied for their effectiveness in the treatment of different diseases, despite their use in traditional Mexican medicine, there is no data on the activity in the CNS. Baring in mind the above, the main aim of this work was to evaluate the effects on the CNS of extract ethanolic of Dracocephalum moldavica L., using the models of the Forced Swimming Test and Tail Suspension Test.…”

Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract

“…Identification of constituents was based in their retention time (RT; min) and on mass spectral fragmentation analysis as well as using of library of National Institute of Standards and technology (NIST 3.0), and by comparison of their spectra fragmentation with the described in the literature data (Estrada-Reyes et al, 2004).…”