Comparative clinical characteristics among different age group of adult COVID‐19 patients: A multicenter study

Abstract

Background Coronavirus disease (COVID‐19) is a global infectious disease with a large burden of illness and high health care costs. This study aimed to compare clinical features among adult COVID‐19 patients in different age groups. Methods Laboratory‐confirmed adult COVID‐19 infection cases between December 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups. Clinical characteristics were compared among different age groups. Results Of 299 cases, median age was 44 and 158 (53%) were male. A total of 53.3% of 30–40 years, 50% of 40–50 years, 36.6% of <30 years and 36.2% of 50–60 years were primary case, none of the elderly were primary case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups ( p < .001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age <30, 30–40, 40–50, 50–65, ≥65, respectively. A total of 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.7%) deaths which occurred among persons ≥65 years. Patients with a history of chronic heart disease had a more than a 56 times higher risk for severe or critical type of COVID‐19 than those without a history of chronic heart disease (odds ratio [OR]: 56.038, 95% confidence interval [CI]: 2.764–1136.053, p = .009). Old age (OR: 1.055, 95% CI: 1.016–1.095, p = .006), high heart rate in admission (OR: 1.085, 95% CI: 1.03–1.144, p = .002), high respiratory rate in admission (OR: 1.635, 95% CI: 1.093–2.431, p = .017) were independently associated with severe or critical type in COVID‐19. Conclusions Proportion of severe or critical type increased with old age groups. Adults with old age and high heart rate, respiratory rate in admission and history of chronic heart disease were associated with severe or critical type in COVID‐19.

Rate of COVID‐19 vaccination among patients with cancer who tested positive for severe acute respiratory syndrome‐coronavirus 2: Analysis of the American Society of Clinical Oncology Registry

“…Access focused on health care providers and residents of long‐term care facilities (phase 1a) 5 . Because of the increased risk of serious complications for older adults, 6–8 the Centers for Disease Control and Prevention updated allocation guidelines in late December 2021 to include all people aged 75 years and older in phase 1b. Phase 1c included all people aged 65–74 years and those aged 16–64 years who had high‐risk medical conditions 5 …”

Vaccination status and outcomes of COVID‐19 patients admitted to a tertiary hospital in Iran during the dominant Delta variant period

“…The higher rate of poor outcomes in patients with comorbidities suggests that the presence of comorbidities is associated with an increased risk and frequent exacerbation of infection. [21][22][23] Additionally, the mortality rate was 4.9% in our hospitalized patients. No significant difference was found in the mortality rate between fully vaccinated and unvaccinated patients in this study.…”

“…Besides, our findings did not indicate any significant difference in terms of poor outcomes between younger and older hospitalized patients. The higher rate of poor outcomes in patients with comorbidities suggests that the presence of comorbidities is associated with an increased risk and frequent exacerbation of infection 21–23 . Additionally, the mortality rate was 4.9% in our hospitalized patients.…”

Initial Signs and Symptoms in Suspected Patients Admitted to Triage Outpatient Clinic of Coronavirus Disease 2019 (COVID-19): A Single-Center Experience

“…Cheng et al reported one-third of participants had one or more chronic diseases in laboratory-confirmed adult COVID-19 infection cases. In their study, patients with a severe or critical type of COVID-19 disease were more likely to have accompanying chronic health issues, including DM, hypertension, chronic heart disease, and chronic pulmonary disease, than a mild or moderate type of COVID-19 disease (27). In a study consisting of COVID-19 confirmed cases followed-by primary healthcare services, 25.4% of the patients had a chronic disease including hypertension (16.8%) and diabetes mellitus (7.0%) (18).…”