Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

A, Thillaikkarasi.

doi:10.18535/jmscr/v5i11.151

Cited by 2 publications

(5 citation statements)

References 8 publications

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“…TA was delivered orally, topically, and through physical methods in these articles. The oral groups patients received a daily dose of 500mg or 750mg [ 11 , 13 , 15 , 18 – 22 , 24 , 27 ]. And the dose of injection TA ranged from 2-8mg to the entire affected area or was 0.2mg/cm 2 in affected area [ 12 , 17 , 24 , 27 – 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…The oral groups patients received a daily dose of 500mg or 750mg [ 11 , 13 , 15 , 18 – 22 , 24 , 27 ]. And the dose of injection TA ranged from 2-8mg to the entire affected area or was 0.2mg/cm 2 in affected area [ 12 , 17 , 24 , 27 – 29 ]. In addition, the form of topical TA included liposome [ 14 ], emulsion/cream [ 16 , 29 ], skin lotion [ 16 , 25 , 37 ], and cataplasm [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…MASI score reduction, defined as change in MASI score before and after treatment, was the primary outcome measure of 12 studies with TA treatment alone [ 12 , 14 , 16 , 17 , 20 , 21 , 23 – 25 , 27 , 29 , 30 ]. Among these studies, 5 trials [ 12 , 17 , 24 , 27 , 29 ] with TA injection were pooled together using the random effects model (SMD, -1.673; 95% CI, -1.990 to -1.356; P < 0.0001; I 2 = 47.6%). Six trials with topical TA were pooled together to be analyzed [ 14 , 16 , 23 , 25 , 29 , 30 ], and the random effects model was applied (SMD, -1.850; 95% CI, -2.556 to -1.144; P < 0.0001; I 2 = 85.6%).…”

Section: Resultsmentioning

confidence: 99%

“…Six trials with topical TA were pooled together to be analyzed [ 14 , 16 , 23 , 25 , 29 , 30 ], and the random effects model was applied (SMD, -1.850; 95% CI, -2.556 to -1.144; P < 0.0001; I 2 = 85.6%). Furthermore, 4 pooled trials [ 20 , 21 , 24 , 27 ] with oral TA were used by the random effects model (SMD, -1.866; 95% CI, -2.456 to -1.276; P < 0.0001; I 2 = 71.6%). Overall, TA treatment alone induced a significant reduction of MASI score (SMD, -1.783; 95% CI, -2.076 to -1.490; P < 0.0001; I 2 = 73.2%).…”

Section: Resultsmentioning

confidence: 99%

“…A recent meta-analysis published during the last few years assessed the effectiveness and safety of TA for melasma [ 40 ]. Compared with previous systematic review, 12 studies [ 11 , 13 – 16 , 21 , 23 , 24 , 27 , 28 , 30 , 37 ] of this review were newly included. And most of these articles are published in 2017 or 2018.…”

Section: Discussionmentioning

confidence: 99%

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Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

Zhang¹,

Tan

Fang

et al. 2018

BioMed Research International

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Objective Melasma is a highly prevalent, chronic, and pigmentary disorder. This systematic review aims to evaluate the efficacy and safety of tranexamic acid (TA) for the treatment of adults with melasma. Methods We independently searched 3 databases from beginning to 26 April, 2018. The study included 21 eligible trials. Two writers extracted data at the same time independently. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (CIs). All statistical analyses were performed using Review Manager Version 5.3 and STATA Version 15.1. Results The combined results showed that the use of TA was associated with reduced Melasma Area and Severity Index (MASI) and Melanin Index (MI). No significant difference in Erythema Index (EI) was observed with TA treatment. Side effects were minor, with a few cases reporting mild gastrointestinal reaction, oligomenorrhoea, hypopigmentation, urticarial rash, and skin irritation xerosis. Conclusion The meta-analysis suggested that TA treatment appeared to be a promising therapeutic approach for melasma.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

Zhang¹,

Tan

Fang

et al. 2018

BioMed Research International

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A Dermoscopic Evaluation of Melasma Treated with Tranexamic Acid

Sarah

Tawfik²,

Soliman

et al. 2022

Open Access Maced J Med Sci

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Background: Melasma is a great challenge to the dermatologist. Choosing the proper treatment and the evaluation method are hard issues. Tranexamic acid [TA] injections showed promising results. The dermoscope is a non -invasive hand held tool Objective: To evaluate the efficacy of TA injections in the management of melasma and to assess a new dermoscopic score for assessment of melasma severity. Patients & Methods: Twenty-seven patients were enrolled in the study. They were assessed clinically, and by dermoscopy. An intradermal tranexamic acid was injected on the melasma. Melasma Area and Severity Index [MASI] was used to assess the melasma. Results: high significant difference was found between pre [4.700±2.1213] and post [2.811±2.0870] treatment values of MASI score [p= 0.0001]. Clinically TA treatment showed a dramatic improvement in MASI. Conclusion: The intradermal usage of TA can actually decrease improved the melasma. This was confirmed by the MASI scores and the dermoscope. The dermoscope could be considered as a useful objective score for melasma.

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Comparative Clinical Study of Oral Tranexamic Acid and Topical Tranexamic Acid with Microneedling in the Management of Melasma

Cited by 2 publications

References 8 publications

Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

A Dermoscopic Evaluation of Melasma Treated with Tranexamic Acid

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